TY - JOUR AU - Mosquera-Rendón, Jeanneth AU - Cárdenas-Brito, Sonia AU - Pineda, Juan D. AU - Corredor, Mauricio AU - Benítez-Páez, Alfonso PY - 2014 DA - 2014/07/10 TI - Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferases JO - BMC Research Notes SP - 440 VL - 7 IS - 1 AB - RNA post-transcriptional modification is an exciting field of research that has evidenced this editing process as a sophisticated epigenetic mechanism to fine tune the ribosome function and to control gene expression. Although tRNA modifications seem to be more relevant for the ribosome function and cell physiology as a whole, some rRNA modifications have also been seen to play pivotal roles, essentially those located in central ribosome regions. RNA methylation at nucleobases and ribose moieties of nucleotides appear to frequently modulate its chemistry and structure. RNA methyltransferases comprise a superfamily of highly specialized enzymes that accomplish a wide variety of modifications. These enzymes exhibit a poor degree of sequence similarity in spite of using a common reaction cofactor and modifying the same substrate type. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-7-440 DO - 10.1186/1756-0500-7-440 ID - Mosquera-Rendón2014 ER -