Figure 5

Sequence similarity characterization among the Class I MTases. Using the entire amino acid profiles from the set of MTases comprising the “Multifunction Cluster” in the Similarity Networks, a multiple sequence alignment was built based on the algorithms specialized in the detection of distant homologs. A - From the multiple sequence alignment, three different Similarity Regions, Regions I-III, with a high degree of conservation, were clearly retrieved. B - The three-dimensional structures depicted in the bottom panels, and regarding the different MTases families of the Multifunction Cluster, show the consensus localization of these Similarity Regions in the respective protein structures.