TY - JOUR AU - Soni, Sangeeta AU - Tyagi, Chetna AU - Grover, Abhinav AU - Goswami, Shyamal K. PY - 2014 DA - 2014/07/11 TI - Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants JO - BMC Research Notes SP - 446 VL - 7 IS - 1 AB - SG2NA is a member of the striatin sub-family of WD-40 repeat proteins. Striatin family members have been associated with diverse physiological functions. SG2NA has also been shown to have roles in cell cycle progression, signal transduction etc. They have been known to interact with a number of proteins including Caveolin and Calmodulin and also propagate the formation of a multimeric protein unit called striatin-interacting phosphatase and kinase. As a pre-requisite for such interaction ability, these proteins are known to be unstable and primarily disordered in their arrangement. Earlier we had identified that it has multiple isoforms (namely 35, 78, 87 kDa based on its molecular weight) which are generated by alternative splicing. However, detailed structural information of SG2NA is still eluding the researchers. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-7-446 DO - 10.1186/1756-0500-7-446 ID - Soni2014 ER -