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Table 1 Demographics, time of CFS-onset, physical health, mental health and clinical site for CFS, healthy and CFS positive control subjects

From: No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank

 

CFS subjects

Healthy subjects

CFS positive control subjects

 

XMRV Positive (n = 5)

XMRV Negative (n = 67)

Total (n = 72)1

XMRV Positive (n = 2)

XMRV Negative (n = 35)

Total (n = 37)1

XMRV Positive (n = 1)

XMRV Negative (n = 19)

Total (n = 20)1

Age ( years ), Mean ( STDEV )

50.4 (4.3)

49.4 (12.0)

49.5 (11.6)

30.0 (17.0)

47.6 (14.3)

46.6 (14.8)

28

51.4 (12.5)

50.0 (13.3)

Age of first CFS symptoms ( years ), Mean ( STDEV )

30.6 (13.2)

34.8 (11.4)

34.5 (11.5)

NA

NA

NA

22

34.3 (12.3)

33.5 (12.2)

Age of CFS diagnosis ( years ), Mean ( STDEV )

37.2 (11.3)

38.4 (11.3)

38.3 (11.2)

NA

NA

NA

24

37.1 (9.7)

36.3 (10.0)

Sex, n (%)

Female

4 (80)

51 (76)

55 (76)

2 (100)

29 (83)

31 (84)

1 (100)

9 (47)

10 (50)

 

Male

1 (20)

15 (22)

16 (22)

0

5 (14)

5 (14)

0

7 (37)

7 (35)

 

Missing data

0

1 (1)

1 (1)

0

1 (3)

1 (3)

0

3 (16)

3 (15)

BMI ( kg / m 2 ) Mean ( STDEV )

26.2 (5.5)

25.9 (6.0)

25.9 (6.0)

21.2 (2.3)

25.6 (6.0)

25.3 (5.9)

18.6

24.6 (4.6)

24.2 (4.7)

Race, n (%)

Caucasian

5 (100)

66 (99)

71 (99)

2 (100)

33 (94)

35 (95)

1 (100)

15 (79)

16 (80)

 

Non-Caucasian

0

0

0

0

0

0

0

1 (5)

1 (5)

 

Missing data

0

1 (1)

1 (1)

0

2 (6)

2 (5)

0

3 (16)

3 (15)

CFS Onset , n (%)

Gradual

2 (40)

16 (24)

18 (25)

NA

NA

NA

0

8 (42)

8 (40)

 

Sudden

3 (60)

50 (75)

53 (74)

NA

NA

NA

1

8 (42)

9 (45)

 

Missing data

0

1 (1)

1 (1)

NA

NA

NA

0

3 (16)

3 (15)

RAND-36 Physical Health Mean ( STDEV )

Physical functioning

20.0 (14.6)

36.3 (21.1)

35.1 (21.1)

1002

85.0 (30.2)

85.4 (29.8)

5

40.0 (28.3)

38.3 (28.6)

 

Role-physical

20.0 (44.7)

2.3 (8.5)

3.5 (14.2)

50

90.7 (28.5)

89.6 (28.9)

0

1.3 (5.7)

1.3 (5.6)

 

Bodily pain

48.0 (22.3)

47.7 (25.1)

47.7 (24.8)

90

84.4 (28.3)

84.6 (27.9)

30

43.8 (24.8)

43.1 (24.3)

 

General health

24.0 (4.2)

24.9 (16.3)

24.9 (15.8)

90

76.1 (21.2)

76.5 (21.0)

10

15.3 (14.3)

15.0 (14.0)

RAND-36 Mental Health Mean ( STDEV )

Vitality

12.0 (10.4)

14.7 (13.7)

14.5 (13.4)

55

68.6 (24.8)

68.2 (24.6)

10

17.9 (18.4)

17.5 (18.0)

 

Social functioning

24.5 (14.5)

28.4 (22.2)

28.1 (21.7)

100

87.2 (26.7)

87.6 (26.4)

0

27.5 (28.1)

26.1 (28.0)

 

Role emotional

86.7 (29.8)

67.2 (44.7)

68.5 (44.0)

100

86.7 (29.4)

87.0 (29.0)

100

56.1 (44.5)

58.3 (44.4)

 

Mental health

67.2 (10.0)

60.7 (16.9)

61.2 (16.6)

68

76.1 (26.3)

75.9 (25.9)

64

53.5 (27.0)

54.0 (26.4)

Clinical Site , n (%)

Florida

0

6 (9)

6 (8)

0

14 (40)

14 (38)

0

0

0

 

North Carolina

4 (80)

16 (24)

20 (28)

2 (100)

7 (20)

9 (24)

0

0

0

 

Pennsylvania

0

1 (1)

1 (1)

0

0

0

0

0

0

 

Nevada

0

0

0

0

0

0

1 (100)

19 (100)

20 (100)

 

Utah

1 (20)

44 (66)

45 (63)

0

14 (40)

14 (38)

0

0

0

  1. Data are derived from the RAND-36 Questionnaire and clinical site enrollment and separated into XMRV-positive and XMRV-negative. The majority of subjects were female and all subjects with race reported were Caucasian. Subject demographics between CFS subjects and Healthy subjects were similar. CFS subjects had lower physical health and mental health scores compared to Healthy subjects. Statistical comparisons between XMRV-positive and XMRV-negative categories were not feasible due to sample size limitations.
  2. CFS: chronic fatigue syndrome; XMRV: xenotropic murine leukemia virus-related virus; STDEV: standard deviation; MD: missing data; NA: not applicable; BMI: body mass index: RAND-36: 36-item health-related quality of life questionnaire.
  3. 1Isolates from a 240 CFS (including 40 CFS Positive Control) and 87 healthy subjects were collected. Of these, 72 CFS, 20 CFS Positive Control and 37 healthy subjects were used in this study.
  4. 2Standard deviation not performed as RAND-36 data only available from one XMRV-positive healthy subject.