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Table 1 Demographics, time of CFS-onset, physical health, mental health and clinical site for CFS, healthy and CFS positive control subjects

From: No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank

  CFS subjects Healthy subjects CFS positive control subjects
  XMRV Positive (n = 5) XMRV Negative (n = 67) Total (n = 72)1 XMRV Positive (n = 2) XMRV Negative (n = 35) Total (n = 37)1 XMRV Positive (n = 1) XMRV Negative (n = 19) Total (n = 20)1
Age ( years ), Mean ( STDEV ) 50.4 (4.3) 49.4 (12.0) 49.5 (11.6) 30.0 (17.0) 47.6 (14.3) 46.6 (14.8) 28 51.4 (12.5) 50.0 (13.3)
Age of first CFS symptoms ( years ), Mean ( STDEV ) 30.6 (13.2) 34.8 (11.4) 34.5 (11.5) NA NA NA 22 34.3 (12.3) 33.5 (12.2)
Age of CFS diagnosis ( years ), Mean ( STDEV ) 37.2 (11.3) 38.4 (11.3) 38.3 (11.2) NA NA NA 24 37.1 (9.7) 36.3 (10.0)
Sex, n (%) Female 4 (80) 51 (76) 55 (76) 2 (100) 29 (83) 31 (84) 1 (100) 9 (47) 10 (50)
  Male 1 (20) 15 (22) 16 (22) 0 5 (14) 5 (14) 0 7 (37) 7 (35)
  Missing data 0 1 (1) 1 (1) 0 1 (3) 1 (3) 0 3 (16) 3 (15)
BMI ( kg / m 2 ) Mean ( STDEV ) 26.2 (5.5) 25.9 (6.0) 25.9 (6.0) 21.2 (2.3) 25.6 (6.0) 25.3 (5.9) 18.6 24.6 (4.6) 24.2 (4.7)
Race, n (%) Caucasian 5 (100) 66 (99) 71 (99) 2 (100) 33 (94) 35 (95) 1 (100) 15 (79) 16 (80)
  Non-Caucasian 0 0 0 0 0 0 0 1 (5) 1 (5)
  Missing data 0 1 (1) 1 (1) 0 2 (6) 2 (5) 0 3 (16) 3 (15)
CFS Onset , n (%) Gradual 2 (40) 16 (24) 18 (25) NA NA NA 0 8 (42) 8 (40)
  Sudden 3 (60) 50 (75) 53 (74) NA NA NA 1 8 (42) 9 (45)
  Missing data 0 1 (1) 1 (1) NA NA NA 0 3 (16) 3 (15)
RAND-36 Physical Health Mean ( STDEV ) Physical functioning 20.0 (14.6) 36.3 (21.1) 35.1 (21.1) 1002 85.0 (30.2) 85.4 (29.8) 5 40.0 (28.3) 38.3 (28.6)
  Role-physical 20.0 (44.7) 2.3 (8.5) 3.5 (14.2) 50 90.7 (28.5) 89.6 (28.9) 0 1.3 (5.7) 1.3 (5.6)
  Bodily pain 48.0 (22.3) 47.7 (25.1) 47.7 (24.8) 90 84.4 (28.3) 84.6 (27.9) 30 43.8 (24.8) 43.1 (24.3)
  General health 24.0 (4.2) 24.9 (16.3) 24.9 (15.8) 90 76.1 (21.2) 76.5 (21.0) 10 15.3 (14.3) 15.0 (14.0)
RAND-36 Mental Health Mean ( STDEV ) Vitality 12.0 (10.4) 14.7 (13.7) 14.5 (13.4) 55 68.6 (24.8) 68.2 (24.6) 10 17.9 (18.4) 17.5 (18.0)
  Social functioning 24.5 (14.5) 28.4 (22.2) 28.1 (21.7) 100 87.2 (26.7) 87.6 (26.4) 0 27.5 (28.1) 26.1 (28.0)
  Role emotional 86.7 (29.8) 67.2 (44.7) 68.5 (44.0) 100 86.7 (29.4) 87.0 (29.0) 100 56.1 (44.5) 58.3 (44.4)
  Mental health 67.2 (10.0) 60.7 (16.9) 61.2 (16.6) 68 76.1 (26.3) 75.9 (25.9) 64 53.5 (27.0) 54.0 (26.4)
Clinical Site , n (%) Florida 0 6 (9) 6 (8) 0 14 (40) 14 (38) 0 0 0
  North Carolina 4 (80) 16 (24) 20 (28) 2 (100) 7 (20) 9 (24) 0 0 0
  Pennsylvania 0 1 (1) 1 (1) 0 0 0 0 0 0
  Nevada 0 0 0 0 0 0 1 (100) 19 (100) 20 (100)
  Utah 1 (20) 44 (66) 45 (63) 0 14 (40) 14 (38) 0 0 0
  1. Data are derived from the RAND-36 Questionnaire and clinical site enrollment and separated into XMRV-positive and XMRV-negative. The majority of subjects were female and all subjects with race reported were Caucasian. Subject demographics between CFS subjects and Healthy subjects were similar. CFS subjects had lower physical health and mental health scores compared to Healthy subjects. Statistical comparisons between XMRV-positive and XMRV-negative categories were not feasible due to sample size limitations.
  2. CFS: chronic fatigue syndrome; XMRV: xenotropic murine leukemia virus-related virus; STDEV: standard deviation; MD: missing data; NA: not applicable; BMI: body mass index: RAND-36: 36-item health-related quality of life questionnaire.
  3. 1Isolates from a 240 CFS (including 40 CFS Positive Control) and 87 healthy subjects were collected. Of these, 72 CFS, 20 CFS Positive Control and 37 healthy subjects were used in this study.
  4. 2Standard deviation not performed as RAND-36 data only available from one XMRV-positive healthy subject.