HMM-ModE: implementation, benchmarking and validation with HMMER3

BMC Research Notes

Table 4 Comparison with PCA-GPCR and HMM-ModE/HMMER2 [9] to classify D1238 and D365 dataset

Dataset	Sub-family	Total	Predicted	Accuracy
Dataset	Sub-family	Total	Predicted	This paper	[9]	[23]
D1238	Rhodopsin like	1103	1030	93.38	95.10	99.91
	Secretin like	84	66	78.57	78.57	98.81
	Metabotropic/glutamate/pheromone	51	47	92.15	60.78	98.04
D365	Rhodopsin like	232	200	86.20	87.50	95.69
	Secretin like	39	23	58.97	58.97	87.18
	Metabotropic/glutamate/pheromone	44	34	77.27	54.54	88.64
	Fungal Pheromone	23	23	100	78.26	95.65
	CAMP receptors	10	10	100	100	100
	Frizzled/smoothened	17	17	100	100	64.71

The accuracy values for the method PCA-GPCR are directly taken from their article. The data in bold depicts the results using HMM-ModE with HMMER3 and HMMER2.

ISSN: 1756-0500