Figure 2

Evaluation of the SST algorithm at the level of the NPA scores. The Pearson correlation coefficients were calculated between the 16 pairs of GPI NPA scores corresponding to the causally inconsistent and pruned causally consistent network versions obtained for the 16 treatment vs. control comparisons contained in the TNF dataset. Only eight network models that were compatible with the tissue context of NHBE cells were considered. The low score correlation for the "Notch" network is consistent with the lack of significant scores for this network, while the poor score correlation for "Replicative Senescence" can be understood in light of the different effective nodal weights for nodes in a region of the network describing MAPK signaling.