Figure 2

Blood flow in arterial branches visualized using time-resolved three-dimensional phase-contrast magnetic resonance imaging. Flows are visualized as streamlines. The regions of branches where flows were measured are shown. Blood flow in the main feeder to the tumor was 65 ml/min (left) before sunitinib treatment, but decreased to 28 ml/min after 8 weeks of sunitinib treatment (right). Of note, flow rates in the other branches increased simultaneously, which may indicate flow redistribution from the tumor to other kidney segments.