Table 3 Comparison of PIMS, PAM, and binary regression identified prognostic signatures

PIMS

Hazard ratio

7.6

2

p-value Log-rank Test

<0.0001

0.0003

AUC

0.81

0.65

AUC p-value

<0.0001

<0.0001

Specificity at 80% sensitivity

0.74

0.37

Cox regression p-value

<0.0001

0.0002

PAM

Hazard ratio

9.3

2

p-value Log-rank Test

<0.0001

0.0004

AUC

0.82

0.62

AUC p-value

<0.0001

0.001

Specificity at 80% sensitivity

0.69

0.31

Cox regression p-value

<0.0001

0.0002

Binary regression

Hazard ratio

4.4

1.4

p-value Log-rank Test

<0.0001

0.063

AUC

0.77

0.57

AUC p-value

<0.0001

0.04

Specificity at 80% sensitivity

0.56

0.32

Cox regression p-value

<0.0001

0.01