Skip to main content

Advertisement

Table 2 Genotypic frequencies according to clinical parameters of the Moroccan CD patients investigated for the L310P polymorphism

From: IL23R and ATG16L1 variants in Moroccan patients with inflammatory bowel disease

   IL23R L310P P value Chi-square
  N CC CT TT   Test
Age of onset 69     0.16 3.7
<17 years 10 6 (60.0) 4 (40.0)    
17-40 52 40 (76.9) 12 (23.1)    
>40 years 7 7 (100.0)     
Sex 69     0.86 0.0
Woman 25 19 (76.0) 6 (24.0)    
Man 44 34 (77.3) 10 (22.7)    
Type 69     0.11 6.1
Fistulizing 26 20 (76.9) 6 (23.1)    
Non fistulizing Non stenosing 24 21 (87.5) 3 (12.5)    
Stenosing 12 9 (75.0) 3 (25.0)    
Fistulizingstenosing 7 3 (42.9) 4 (57.1)    
Localization 69     0.29 9.6
L1 19 16 (84.2) 3 (15.8)    
L1 + P 2 2 (100.0) -    
L2 10 6 (60.0) 4 (40.0)    
L2 + P 7 7 (100.0) -    
L3 19 13 (68.4) 6 (31.6)    
L3 + P 1 - 1 (100.0)    
L4 2 2 -    
L4 + L2 4 3 (75.0) 1 (25.0)    
P 5 4 (80.0) 1 (20.0)    
SFC 69     0.60 0.3
Presence 4 4 (100.0) -    
Absence 65 49 (75.4) 16 (24.6)    
Smoking 69     1.0 0.0
Presence 28 22 (78.6) 6 (21.4)    
Absence 41 31 (75.6) 10 (24.4)    
Appendectomy 69     0.73 0.12
Presence 9 6 (66.7) 3 (33.3)    
Absence 60 47 (78.3) 13 (21.7)    
EIM 69     0.14 2.14
Presence 39 33 (84.6) 6 (15.4)    
Absence 30 20 (66.7) 10 (33.3)    
Surgery 69     0.30 1.1
Presence 29 20 (69.0) 9 (31.0)    
Absence 40 33 (82.5) 7 (17.5)    
  1. (SFC: Similar familial cases; EIM: Extra intestinal manifestations; N: Total number; CC: wild type IL23R L310P, CT: IL23R L310P heterozygous variant, TT: IL23R L310P homozygous variant).