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Table 5 Genotypic frequencies according to clinical parameters of the Moroccan UC patients investigated for the T300Apolymorphism

From: IL23R and ATG16L1 variants in Moroccan patients with inflammatory bowel disease

Clinical parameters N ATG16L1T300A P value Chi-deux test
AA AG GG
Age of onset 30     0.12 4.32
<17 years -      
17-40 21 10 (47.6) 8 (38.1) 3 (14.3)   
>40 years 9 1 (11.1) 7 (77.8) 1 (11.1)   
Sex 30     0.41 1.76
Woman 14 4 (28.6) 7 (50.0) 3 (21.4)   
Man 16 7 (43.8) 8 (50.0) 1 (6.3)   
Localization 30     0.71 3.73
Leftcolitis 11 5 (45.5) 5 (45.5) 1 (9.1)   
Extensive colitis 2 - 2 (100.0) -   
Pancolitis 13 4 (30.8) 7 (53.8) 2 (15.4)   
Proctitis 4 2 (50.0) 1 (25.0) 1 (25.0)   
SFC 30     0.41 1.79
Presence 1 1 (100.0) - -   
Absence 29 10 (34.5) 15 (51.7) 4 (13.8)   
Smoking 30     0.19 3.36
Presence 8 5 (62.5) 2 (25.0) 1 (12.5)   
Absence 22 6 (27. 3) 13 (59.1) 3 (13.6)   
Appendectomy 30     0.05 6.20
Presence - - - -   
Absence 30 11 (36.7) 15 (50.0) 4 (13.3)   
EIM 30     0.50 1.38
Presence 17 7 (41.2) 7 (41.2) 3 (17.6)   
Absence 13 4 (30.8) 8 (61.5) 1 (7.7)   
Surgery 30     0.22 3.04
Presence 4 3 (75.0) 1 (25.0) -   
Absence 26 8 (30.8) 14 (53.8) 4 (15.4)   
  1. (SFC: Similar familial cases; EIM: Extra intestinal manifestations; N: Total number; AA: wild type ATG16L1 T300A, AG: ATG16L1 T300A heterozygous variant, GG: ATG16L1 T300A homozygous variant).