Skip to main content

Table 6 Genotypic frequencies according to clinical parameters of the Moroccan UC patients investigated for the L310P polymorphism

From: IL23R and ATG16L1 variants in Moroccan patients with inflammatory bowel disease

Clinical parameters N IL23L310P P value Chi-deux test
CC CT TT
Age of onset 30     0.31 2.34
<17 years - - - -   
17-40 21 16 (76.2) 4 (19.0) 1 (4.8)   
>40 years 9 5 (55.6) 4 (44.4) -   
Sex 30     0.30 2.93
Woman 14 11 (78.6) 2 (14.3) 1 (7.1)   
Man 16 10 (62.5) 6 (37.5) -   
Localization 30     0.43 5.95
Leftcolitis 11 6 (54.5) 5 (45.5) -   
Extensive colitis 2 1 (50.0) 1 (50.0) -   
Pancolitis 13 10 (76.9) 2 (15.4) 1 (7.7)   
Proctitis 4 4 (100.0) - -   
SFC 30     0.80 0.44
Presence 1 1 (100.0) - -   
Absence 29 20 (69.0) 8 (27.6) 1 (3.4)   
Smoking 30     0.81 0.41
Presence 8 6 (75.0) 2 (25.0) -   
Absence 22 15 (68.2) 6 (27.3) 1 (4.5)   
Appendectomy 30     <0.0001 20.60
Presence - - - -   
Absence 30 21 (70.0) 8 (26.7) 1 (3.3)   
EIM 30     0.60 1.03
Presence 17 11 (64.7) 5 (29.4) 1 (5.9)   
Absence 13 10 (76.9) 3 (23.1) -   
Surgery 30     0.37 1.98
Presence 26 17 (65.4) 8 (30.8) 1 (3.8)   
Absence 4 4 (100.0) - -   
  1. (SFC: Similar familial cases; EIM: Extra intestinal manifestations; N: Total number; CC: wild type IL23R L310P, CT: IL23R L310P heterozygous variant, TT: IL23R L310P homozygous variant).