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Table 5 KEGG pathway analysis of 12 miRNAs included in the UDB using DIANA-mirpath [[25]]

From: Universal disease biomarker: can a fixed set of blood microRNAs diagnose multiple diseases?

 

KEGG.pathway

p.value

# of genes

# of miRNAs

1

Prion diseases

0.00e+00

6

2

2

Pathways in cancer

3.00e-13

39

6

3

PI3K-Akt signaling pathway

1.07e-11

43

4

4

TGF-beta signaling pathway

5.98e-10

14

4

5

Viral carcinogenesis

1.56e-09

27

5

6

Ribosome

6.04e-09

22

1

7

Small cell lung cancer

6.33e-09

17

5

8

Colorectal cancer

1.02e-08

9

6

9

Ribosome biogenesis

2.02e-08

20

1

 

in eukaryotes

   

10

p53 signaling pathway

6.75e-08

16

5

11

RNA transport

1.19e-07

28

1

12

Cell cycle

1.56e-07

22

3

13

Pancreatic cancer

2.75e-07

11

5

14

Hepatitis B

1.17e-06

12

5

15

Prostate cancer

4.64e-06

16

5

16

Bladder cancer

6.94e-06

7

4

17

Chronic myeloid leukemia

2.01e-05

8

4

18

Measles

1.28e-04

19

5

19

Protein export

3.29e-04

9

1

20

Non-small cell lung cancer

3.69e-04

6

5

21

HTLV-I infection

1.43e-03

11

3

22

Glioma

1.46e-03

6

3

23

Melanoma

1.71e-03

7

5

24

Transcriptional misregulation

1.22e-02

9

3

 

in cancer

   

25

Oocyte meiosis

1.36e-02

14

1

26

Focal adhesion

1.50e-02

8

3

27

Epstein-Barr virus infection

2.45e-02

19

3

  1. Bold faces: tumors/cancers, Bold italic: other diseases, Italic: tumors/cancers related, *parts of “Pathways in cancer”, and surrounded by blue rectangular in Figure 3.