Table 3 Fold change of gene expression in retinal pigment epithelial cells exposed to ranibizumab compared to human vascular endothelial growth factor-treated control
Gene symbol | Gene name | Ranibizumab/control | Grade |
|---|---|---|---|
NOS3 | Nitric oxide synthase | -293.5515 | A |
KDR | Kinase insert domain receptor | -5.0041 | A |
MAPK3 | Mitogen-activated protein kinase 3 | +20.0674 | A |
VEGFA | Vascular endothelial growth factor | +73.4215 | A |
PIK3CG | Phosphoinositide-3-kinase, catalytic, gamma polypeptide | +7.1785 | A |
SPHK1 | Sphingosine kinase 1 | +28.9047 | A |
PLA2G2E | Phospholipase A2, group IIE | -26.829 | B |
PLA2G2F | Phospholipase A2, group IIF | -123.5516 | B |
PLA2G2A | Phospholipase A2, group IIA (platelets, synovial fluid) | -12.4228 | B |
PLA2G1B | Phospholipase A2, group IB | -89.4568 | B |