Table 2 Correspondence between conserved hydrophobic residues in multiple alignments and packing residues in 3D structure

3α structure

Conserved hydrophobic residues

9-L, 12-A, 16-A, 20-L, 29-Y, 32-L(+), 33-I, 36-A, 39-V, 42-V, 45-L(+), 49-I

Packing residues in 2LHC

16-A, 20-L, 30-F, 33-I, 42-V, 45-L

Packing residues in 2LHG

16-A, 20-L, 25-I, 33-I, 42-V, 45-L

4β + α structure

Conserved hydrophobic residues

5-L(+), 20-A(+), 21-V, 23-A(+), 26-A, 30-F(+), 34-A(+), 43-W, 45-Y, 52-F(+), 54-V

Packing residues in 2LHD

16-A, 20-L, 26-A, 30-F, 34-A, 43-W

Packing residues in 2LHE

16-A, 20-L, 25-I, 34-A, 43-W