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Table 2 Genotyping results of the patient for genes implicated in drug disposition of fluvastatin and/or telmisartan

From: Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report

Gene

Variant

Genotype

Function in fluvastatin and telmisartan disposition

OATP1B1

 

Hepatocellular uptake of Fluvastatin

 

SLCO1B1 c.521T>C

TT

 
 

SLCO1B1 c.388A>G

AG

 

OATP1B3

 

Hepatic uptake of fluvastatin and telmisartan

 

SLCO1B3 c.699A>G

AA

 

OATP2B1

 

Cellular uptake of telmisartan.

 

SLCO2B1 c. 935G>A

GG

 
 

SLCO2B1 c.1457C>T

CC

 

MRP2 (ABCC2)

 

Biliary elimination of telmisartan acylglucuronide

 

ABCC2 -24C>T

CT

 
 

ABCC2 c.1294G>A

GG

 
 

ABCC2 c.3972C>T

CC

 

BCRP (ABCG2)

 

Biliary elimination of telmisartan acylglucuronide

 

ABCG2 c421C>T

CC

 

CYP2C9 * 3

 

Biliary elimination of fluvastatin.

 

CYP2C9 c.1075A>C

CT