Gene | Variant | Genotype | Function in fluvastatin and telmisartan disposition |
---|---|---|---|
OATP1B1 | Hepatocellular uptake of Fluvastatin | ||
SLCO1B1 c.521T>C | TT | ||
SLCO1B1 c.388A>G | AG | ||
OATP1B3 | Hepatic uptake of fluvastatin and telmisartan | ||
SLCO1B3 c.699A>G | AA | ||
OATP2B1 | Cellular uptake of telmisartan. | ||
SLCO2B1 c. 935G>A | GG | ||
SLCO2B1 c.1457C>T | CC | ||
MRP2 (ABCC2) | Biliary elimination of telmisartan acylglucuronide | ||
ABCC2 -24C>T | CT | ||
ABCC2 c.1294G>A | GG | ||
ABCC2 c.3972C>T | CC | ||
BCRP (ABCG2) | Biliary elimination of telmisartan acylglucuronide | ||
ABCG2 c421C>T | CC | ||
CYP2C9 * 3 | Biliary elimination of fluvastatin. | ||
CYP2C9 c.1075A>C | CT |