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Table 3 Parameters from ROC analysis on serum Trx1 levels in patients with various cancers

From: Thioredoxin 1 as a serum marker for breast cancer and its use in combination with CEA or CA15-3 for improving the sensitivity of breast cancer diagnoses

Type of cancer

AUC* (±SEM)

Sensitivity (%)

Specificity (%)

Criterion (ng/ml)

# of serum (Grade)

Breast/NFM

0.911 ± 0.179

89.3

78.0

>32.3390

197 (I/II/III)

Colorectal/NFM

0.687 ± 0.0425

68.3

61.0

>29.0533

64 (I/II/III)

Kidney/NFM

0.633 ± 0.0617

46.7

81.0

>32.9986

30 (I/II)

Lung/NFM

0.643 ± 0.0381

54.1

73.0

>31.1820

108 (I/II/III/IV)

Normal Control

-

-

-

-

100 F/M: 50 F / 50 M

  1. *P < 0.0001.