Figure 2
Lesions sizes in L. braziliensis -infected C57BL/6 mice in which L. amazonensis and L. braziliensis extracts had been injected. The animals (n = 4–6 per group) were treated with intradermal injections of the vehicle (Saline C57BL/6) or of L. amazonensis (LaE BALB/c and LaE C57BL/6) or L. braziliensis (LbE C57BL/6) extracts containing 5 μg of protein, one week before being infected with 107 L. braziliensis promastigotes in the stationary phase of growth. The lines in A and C join the median values of the results from each group in each week, and the vertical bars represent the interquartile interval. Comparisons between the groups of extract-injected and the group of saline-injected mice were performed by Mann–Whitney U test (level of significance = 0.0056). *P < 0.001.