Effect of PLX4032 and PLX4720 on ABCC1 activity. A) Influence of PLX4032 or PLX4720 on 5-CFDA (1 μM) fluorescence in G62 cells, B) time kinetics of 5-CFDA (1 μM) fluorescence in G62 cells in the presence of PLX4032 or PLX4720 after a 60 min pre-incubation period with subsequent wash-out of extracellular 5-CFDA and PLX4032 or PLX4720 (control = 5-CFDA incubation in the absence of drugs). C) ABCC1 ATPase activity in isolated membranes in the presence of PLX4032 or PLX4720 (control = activity in the absence of drugs). NEM-GS, a known ABCC1 substrate, was used for comparison. *P < 0.05 relative to non-treated controls.