Table 4 Deleterious mutations identified in high grade serous ovarian cancer samples
Sample ID | Gene | Mutation | Codon change | Protein change | Type | dbSNP ID/COSMIC ID | transFIC prediction |
|---|---|---|---|---|---|---|---|
T1 | TP53 | g.chr17:7578406C > T | c.(523–525)CGC > CAC | p.R175H | SNP | rs28934578 | Driver mutation |
T2 | TP53 | g.chr17:7578271T > C | c.(577–579)CAT > CGT | p.H193R | SNP | COSM10742 | Driver mutation |
T3 | TP53 | g.chr17:7578190T > C | c.(658–660)TAT > TGT | p.Y220C | SNP | rs121912666 | Driver mutation |
T4 | TP53 | g.chr17:7578442T > C | c.(487–489)TAC > TGC | p.Y163C | SNP | rs148924904 | Strongly affecting mutation |
T5 | TP53 | g.chr17:7578190T > C | c.(658–660)TAT > TGT | p.Y220C | SNP | rs121912666 | Driver mutation |
T6 | TP53 | g.chr17:7577094G > C | c.(844–846)CGG > GGG | p.R282G | SNP | rs28934574 | Driver mutation |
T8 | TP53 | g.chr17:7578406C > T | c.(523–525)CGC > CAC | p.R175H | SNP | rs28934578 | Driver mutation |
T9 | TP53 | g.chr17:7577581A > G | c.(700–702)TAC > CAC | p.Y234H | SNP | COSM11152 | Driver mutation |