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Table 4 Deleterious mutations identified in high grade serous ovarian cancer samples

From: Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach

Sample ID Gene Mutation Codon change Protein change Type dbSNP ID/COSMIC ID transFIC prediction
T1 TP53 g.chr17:7578406C > T c.(523–525)CGC > CAC p.R175H SNP rs28934578 Driver mutation
T2 TP53 g.chr17:7578271T > C c.(577–579)CAT > CGT p.H193R SNP COSM10742 Driver mutation
T3 TP53 g.chr17:7578190T > C c.(658–660)TAT > TGT p.Y220C SNP rs121912666 Driver mutation
T4 TP53 g.chr17:7578442T > C c.(487–489)TAC > TGC p.Y163C SNP rs148924904 Strongly affecting mutation
T5 TP53 g.chr17:7578190T > C c.(658–660)TAT > TGT p.Y220C SNP rs121912666 Driver mutation
T6 TP53 g.chr17:7577094G > C c.(844–846)CGG > GGG p.R282G SNP rs28934574 Driver mutation
T8 TP53 g.chr17:7578406C > T c.(523–525)CGC > CAC p.R175H SNP rs28934578 Driver mutation
T9 TP53 g.chr17:7577581A > G c.(700–702)TAC > CAC p.Y234H SNP COSM11152 Driver mutation
  1. SNP = single nucleotide polymorphism.