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Table 5 Comparison of TP53 deleterious mutations in this study with ICGC data

From: Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach

  p.R175H p.H193R p.Y220C p.Y163C p.R282G p.Y234H
ICGC mutation ID MU7870 MU13250 MU4807 MU10836 MU34029 MU622929
Occurrences Affects 66 distinct donors across 12 cancer projects Affects 9 distinct donors across 4 cancer projects Affects 24 distinct donors across 9 cancer projects Affects 13 distinct donors across 7 cancer projects Affects 2 distinct donors across 2 cancer projects Affects 1 distinct donors across 1 cancer project
Occurrences in serous ovarian cancer (ICGC) 6/278 (2.16%) 1/278 (0.36%) 4/278 (1.44%) 1/278 (0.36) None reported None reported
Occurrences in serous ovarian cancer (this study) 2/10 (20%) 1/10 (10%) 2/10 (20%) 1/10 (10%) 1/10 (10%) 1/10 (10%)
Other cancers involved Brain cancer (5/269 (1.86%)) Endometrial cancer (6/766 (0.78%)) Brain cancer (2/269 (0.74%)) Breast cancer (2/117 (1.71%)) Lung cancer (1/111 (0.9%)) Renal cancer (1/407 (0.25%))
Breast cancer (15/766 (1.96%)) Lung cancer (1/246 (0.41%)) Breast cancer (2/117 (1.71%)) Breast cancer (2/766 (0.26%)) Breast cancer (1/943 (0.11%))  
Colon cancer 15/261 (5.75%)) Breast cancer (1/178 (0.56%)) Breast cancer (6/766 (0.78%)) Colon cancer (1/261 (0.38%))   
Endometrial cancer (2/246 (0.81%))   Colon cancer 2/261 (0.77%)) Liver cancer (3/213 (1.41%))   
Esophageal cancer (2/22 (9.09%))   Endometrial cancer (3/246 (1.22%)) Lung cancer (3/178 (1.69%))   
Gastric cancer (1/10 (10.00%))   Liver cancer (1/42 (2.38%)) Pancreatic cancer (1/187 (0.53%))   
Oral cancer (2/50 (4.00%))   Lung cancer (2/178 (1.12%))    
Pancreatic cancer (8/187 (4.28%) and 3/85 (3.53%))   Pancreatic cancer (2/187 (1.07%))    
Pediatric brain tumors (1/193 (0.52%))      
Rectal cancer (6/109 (5.50%))      
  1. Frequency of TP53 mutations from this study in comparison with ICGC data. Information was extracted from the data portal (Zhang et al. [20]) and no post-analysis modification was made.