From: Contribution of syndecan-4 genetic variants to hypertension, the TAMRISK study
P* | ||||||
---|---|---|---|---|---|---|
rs4599 | C/C | T/C | T/T | Additive | Dominant (TT) | Recessive (CC) |
n | 32 | 287 | 448 | |||
Hypertension % | 39 | 31 | 35 | 0.496 | 0.225 | 0.334 |
Coronary artery disease % (n=31) | 10 | 5 | 3 | 0.057 | 0.061 | 0.108 |
Systolic blood pressure (mm Hg) at 45 | 133.6 (15.3) | 132.2 (13.5) | 133.0 (14.3) | 0.735 | 0.542 | 0.750 |
Systolic blood pressure (mm Hg) at 50 | 136.8 (12.7) | 134.7 (16.7) | 135.3 (17.1) | 0.771 | 0.738 | 0.485 |
Diastolic blood pressure (mm Hg) at 45 | 83.6 (7.5) | 85.1 (9.0) | 85.6 (9.5) | 0.471 | 0.329 | 0.330 |
Diastolic blood pressure (mm Hg) at 50 | 87.3 (8.4) | 88.0 (10.1) | 88.1 (9.7) | 0.904 | 0.780 | 0.640 |
Body mass index (kg/m 2 ) at 45 | 27.4 (4.5) | 26.5 (4.3) | 26.3 (4.2) | 0.368 | 0.368 | 0.215 |
Body mass index (kg/m 2 ) at 50 | 27.6 (4.5) | 26.9 (4.7) | 26.9 (4.7) | 0.776 | 0.776 | 0.438 |
rs1981429 | G/G | T/G | T/T | Additive | Dominant (TT) | Recessive (GG) |
n | 185 | 396 | 186 | |||
Hypertension % | 32 | 32 | 41 | 0.074 | 0.015 | 0.283 |
Coronary artery disease % (n=31) | 2 | 3 | 7 | 0.013 | 0.010 | 0.056 |
Systolic blood pressure (mm Hg) at 45 | 133.6 (15.7) | 131.5 (13.7) | 134.2 (14.2) | 0.086 | 0.108 | 0.379 |
Systolic blood pressure (mm Hg) at 50 | 133.1 (16.7) | 135.4 (17.3) | 136.2 (15.9) | 0.157 | 0.252 | 0.064 |
Diastolic blood pressure (mm Hg) at 45 | 85.9 (10.0) | 84.4 (8.8) | 86.7 (9.4) | 0.018 | 0.025 | 0.408 |
Diastolic blood pressure (mm Hg) at 50 | 87.1 (9.6) | 88.4 (10.1) | 87.9 (9.2) | 0.330 | 0.928 | 0.161 |
Body mass index (kg/m 2 ) at 45 | 26.4 (4.0) | 26.1 (4.0) | 27.2 (4.7) | 0.024 | 0.008 | 0.832 |
Body mass index (kg/m 2 ) at 50 | 27.1 (4.5) | 26.6 (4.4) | 27.6 (5.2) | 0.038 | 0.026 | 0.629 |