|
Number of helminth infections
|
Spontaneous cytokine production
|
|---|
|
n (%)
|
% Non-responders
|
% Responders
|
Crude
|
Adjusted
|
|---|
| |
(n)
|
(n)
|
#OR (95% CI)
|
##OR (95% CI)
|
|---|
|
IFN-γ [mean (pg/mL) = 21.0]*
|
| | |
(n = 870)
|
(n = 114)
| | |
|
0
|
450 (445.7)
|
89.8
|
10.2
|
1
|
1
|
|
1
|
361 (36.7)
|
87.8
|
12.2
|
1.22 (0.79; 1.89)
|
1.17 (0.74; 1.84)
|
|
2
|
117 (11.9)
|
86.3
|
13.7
|
1.39 (0.76; 2.56)
|
1.35 (0.72; 2.53)
|
|
3
|
56 (5.7)
|
85.7
|
14.3
|
1.46 (0.65; 3.28)
|
1.36 (0.59; 3.11)
|
|
IL-5 [mean (pg/mL) = 16.0]*
|
| | |
(n = 1.150)
|
(n = 66)
| | |
|
0
|
569 (46.8)
|
95.1
|
4.9
|
1
|
1
|
|
1
|
443 (36.4)
|
94.1
|
5.9
|
1.20 (0.70; 2.09)
|
1.18 (0.67; 2.07)
|
|
2
|
144 (11.8)
|
95.8
|
4.2
|
0.84 (0.34; 2.07)
|
0.86 (0.34; 2.15)
|
|
3
|
60 (5.0)
|
90.0
|
10.0
|
2.15 (0.85; 5.41)
|
2.18 (0.84; 5.67)
|
|
IL-10 [mean (pg/mL) = 35.6]*
|
| | |
(n = 1.213)
|
(n = 110)
| | |
|
0
|
610 (46.1)
|
95.1
|
4.9
|
1
|
1
|
|
1
|
482 (36.4)
|
90.7
|
9.3
|
1.99 (1.23; 3.21)
|
1.99 (1.22; 3.24)
|
|
2
|
164 (12.4)
|
88.4
|
11.6
|
2.53 (1.39; 4.63)
|
2.45 (1.32; 4.55)
|
|
3
|
67 (5.1)
|
76.1
|
23.9
|
6.07 (3.10; 11.86)
|
5.97 (2.97; 12.01)
|
|
IL-13 [mean (pg/mL) = 85.6]*
|
| | |
(n = 826)
|
(n = 432)
| | |
|
0
|
542 (45.5)
|
65.4
|
34.6
|
1
|
1
|
|
1
|
458 (36.4)
|
66.6
|
33.4
|
0.95 (0.73; 1.23)
|
0.96 (0.73; 1.24)
|
|
2
|
152 (12.1)
|
64.5
|
35.5
|
1.04 (0.72; 1.51)
|
1.07 (0.73; 1.57)
|
|
3
|
64 (5.0)
|
64.1
|
35.9
|
1.06 (0.62; 1.82)
|
1.10 (0.63; 1.91)
|
- #Crude logist analysis. ##Logist analysis adjusted for gender, age, maternal education and parental asthma. *Geometric mean; Numbers in bold are statistically significant at P < 0.05. OR – odds ratio. 95% CI – 95% confidence interval.
