Long-term follow-up of nephrotoxicity in rats administered both melamine and cyanuric acid

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Table 1 Serum and urinary biochemical findings

Age	6 weeks old		10 weeks old		26 weeks old
Group	Control	Group M + C	Control	Group M + C	Control	Group M + C
Serum Cr (mg/dL)	0.23 ± 0.05	0.68 ± 0.27*	0.25 ± 0.04	0.55 ± 0.24*	0.32 ± 0.08	0.45 ± 0.20*
Serum BUN (mg/dL)	18.8 ± 1.66	61.4 ± 28.4*	19.1 ± 1.84	52.4 ± 24.8*	28.8 ± 5.11	30.8 ± 11.8
Seruma Ca (mg/dL)	9.57 ± 0.12	9.55 ± 0.19	9.04 ± 0.23	9.56 ± 0.33	9.34 ± 0.24	9.44 ± 0.35
Serum P (mg/dL)	9.02 ± 0.25	8.02 ± 0.93	8.91 ± 0.30	8.61 ± 0.88	8.75 ± 0.28	8.81 ± 0.48
Urine volume (mL)	19.3 ± 3.4	82.2 ± 33.9*	21.3 ± 8.3	67.3 ± 30.3	38.3 ± 13.3	48.3 ± 23.3
Urine pH	7.60 ± 0.45	8.00 ± 0.40	7.40 ± 0.50	7.60 ± 0.45	7.50 ± 0.50	7.55 ± 0.60
Urine Ca (mmol/g/Cr)	0.06 ± 0.03	0.19 ± 0.12	0.06 ± 0.08	0.10 ± 0.18	0.10 ± 0.12	0.08 ± 0.12
Urine P (mmol/g/Cr)	3.16 ± 1.07	2.13 ± 2.36	3.09 ± 1.03	2.98 ± 2.01	3.12 ± 1.13	3.07 ± 2.03
Urine Mg (mmol/g/Cr)	0.17 ± 0.15	0.78 ± 1.15	0.15 ± 0.22	0.23 ± 0.52	0.18 ± 0.14	0.15 ± 0.34
Pathological severity of renal injury	0.17 ± 0.41	4.17 ± 0.75*	0.33 ± 0.52	3.83 ± 0.75*	0.83 ± 0.75	2.66 ± 0.52*

Serum levels, urinary biochemical findings, and pathological severity of renal injury according to age in male rats at 28 days after melamine and cyanuric aid administration compared to the control rats.
Data are presented as the mean ± SD.
Abbreviations: Cr creatinine; BUN blood urea nitrogen; Ca calcium; P phosphorus; Mg magnesium.
*P < 0.05, versus the control group.

ISSN: 1756-0500