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Table 2 Summary of chromosome aberration assay results

From: Hydroxytyrosol: lack of clastogenicity in a bone marrow chromosome aberration study in rats

Study groups (n = 5/sex) Metaphases Aberrant cells excluding gaps Gaps Polyploid cells Mitotic index (% ± SD)
   Number (% ± SD)    
Negative Control, 24 h       
 Male 500 6 1.2 ± 1.1 5 0 11.3
 Female 500 5 1.3 ± 1.4 8 0 8.4
Treatment Group, 24 h       
 Male 500 0 0.0 ± 0.0* 4 0 11.0
 Female 500 2 0.4 ± 0.9 7 0 10.1
Negative Control, 48 h       
 Male 500 3 0.6 ± 1.6 4 4 10.7
 Female 500 0 0.0 ± 0.0 3 0 11.4
Treatment Group, 48 h       
 Male 500 1 0.2 ± 0.4 5 0 14.3
 Female 500 1 0.2 ± 0.4 3 1 13.4
Positive Control, 24 h       
 Male 250 100 40.0 ± 12.3* 6 1 3.1*
 Female 250 108 43.2 ± 4.9* 11 0 2.5*
  1. *Significantly different from negative control (distilled water) (p < 0.05).
  2. n = number of animals; SD = standard deviation.