Table 2 Summary of chromosome aberration assay results
From: Hydroxytyrosol: lack of clastogenicity in a bone marrow chromosome aberration study in rats
Study groups (n = 5/sex) | Metaphases | Aberrant cells excluding gaps | Gaps | Polyploid cells | Mitotic index (% ± SD) | |
|---|---|---|---|---|---|---|
Number | (% ± SD) | |||||
Negative Control, 24 h | ||||||
Male | 500 | 6 | 1.2 ± 1.1 | 5 | 0 | 11.3 |
Female | 500 | 5 | 1.3 ± 1.4 | 8 | 0 | 8.4 |
Treatment Group, 24 h | ||||||
Male | 500 | 0 | 0.0 ± 0.0* | 4 | 0 | 11.0 |
Female | 500 | 2 | 0.4 ± 0.9 | 7 | 0 | 10.1 |
Negative Control, 48 h | ||||||
Male | 500 | 3 | 0.6 ± 1.6 | 4 | 4 | 10.7 |
Female | 500 | 0 | 0.0 ± 0.0 | 3 | 0 | 11.4 |
Treatment Group, 48 h | ||||||
Male | 500 | 1 | 0.2 ± 0.4 | 5 | 0 | 14.3 |
Female | 500 | 1 | 0.2 ± 0.4 | 3 | 1 | 13.4 |
Positive Control, 24 h | ||||||
Male | 250 | 100 | 40.0 ± 12.3* | 6 | 1 | 3.1* |
Female | 250 | 108 | 43.2 ± 4.9* | 11 | 0 | 2.5* |