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Table 3 Summary of findings table

From: Vitamin D supplementation in children with asthma: a systematic review and meta-analysis

Vitamin D compared to No vitamin D for children with asthma

Outcomes

No of participants (studies) follow up

Quality of the evidence (GRADE)

Anticipated effects

Asthma related symptoms

116

Heterogeneous and not definitive data, not pooled

Different instruments/scales

(3 studies)

VERY LOW 1,2,3

 

1.5-12 months

due to risk of bias, heterogeneity, imprecision

FEV1

82

The mean FEV1 in the intervention groups was

 

(2 studies)

LOW 3,4,5

0.54 lower (5.28 lower to 4.19 higher)

 

6-12 months

due to risk of bias, imprecision

 

Vitamin D levels

116

The mean vitamin D levels in the intervention groups was

 

(3 studies)

VERY LOW 1,6,7

6.6 higher (0.6 lower to 13.8 higher)

 

1.5-6 months

due to risk of bias, heterogeneity, imprecision

 
  1. GRADE Working Group grades of evidence.
  2. High quality: Further research is very unlikely to change our confidence in the estimate of effect.
  3. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
  4. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
  5. Very low quality: We are very uncertain about the estimate.
  6. 1None of the studies reported the methods of allocation concealment, and the use of intention to treat analysis. Schou 2003 had missing data for 12% of participants. 2High degree of unexplained heterogeneity with I2 = 86%.
  7. 3Wide confidence interval, including both values suggesting harms and values suggesting benefits.
  8. 4None of the studies reported the methods of allocation concealment, and the use of intention to treat analysis.
  9. 5Borderline degree of heterogeneity, I2 = 54%.
  10. 6High degree of unexplained heterogeneity with I2 = 97%.
  11. 7Wide confidence interval, including values suggesting no effect and values suggesting benefit.