Donors (n = 34) | ||
---|---|---|
 | rhEPO-b treated n = 19 | Placebo n = 20 |
Demographics | Â | Â |
age (yrs) median(IQR) | 52 (45-58) | 53 (46-66) |
male n (%) | 10 (53%) | 13 (65%) |
ethnicity white n (%) | 19 (100%) | 20 (100%) |
Cause of death n (%) | Â | Â |
intra-cranial haemorrhage | 14 (74%) | 14 (70%) |
other intra-cranial event | 1 (5%) | 4 (20%) |
extra-cranial event | 4 (21%) | 2 (10%) |
Donated kidney | Â | Â |
ECD kidney n (%) | 7 (37%) | 10 (50%) |
DCD kidney n (%) | 12 (63%) | 10 (50%) |
inotropic support n (%) | 12 (63%) | 16 (80%) |
vasopressin n (%) | 9 (47%) | 11 (55%) |
final creatinine (μmol/L) median(IQR) | 61(51-87) | 77(66-96) |
warm ischaemic time1 mins (range) | 17 (12-22) | 17 (13-20) |
DCD only | ||
Recipients (n = 40) | ||
Demographics | Â | Â |
age (yrs) median(IQR) | 51 (43-63) | 54 (41-63) |
male n (%) | 10 (53%) | 14 (70%) |
White | 13 (68%) | 19 (95%) |
Asian | 5 (27%) | 1 (5%) |
Afro-Caribbean | 1 (5%) | 0 |
BMI median(IQR) | 25 (23-27) | 25 (23-29) |
Cause of ESRD n (%) | Â | Â |
glomerular disease | 8 (42%) | 6 (30%) |
hypertension | 1 (5%) | 3 (15%) |
reflux nephropathy | 4 (21%) | 3 (15%) |
other | 6 (32%) | 8 (40%) |
Mode of dialysis pre-transplant n (%) | Â | Â |
haemodialysis | 9 (47%) | 12 (60%) |
peritoneal dialysis | 8 (42%) | 7 (35%) |
pre-dialysis | 2 (11%) | 1 (5%) |
months on dialysis median(IQR) | 30 (16-51) | 42 (22-52) |
previous transplant n (%) | 3 (16%) | 5 (25%) |
anuric pre-transplant n (%) | 6 (32%) | 7 (35%) |
diabetes n (%) | 1 (5%) | 0 |
hypertension n (%) | 17 (90%) | 17 (85%) |
rhEPO pre-transplant n (%) | 17 (90%) | 17 (85%) |
days before transplant of last rhEPO median (IQR) | 5 (4-11.5) | 4.5 (1.8-11.0) |
PRA% | Â | Â |
0-5 | 14 | 14 |
6-84 | 4 | 5 |
>84 | 1 | 1 |
HLA mismatches | Â | Â |
0 | 5 | 4 |
1-2 | 5 | 6 |
3-4 | 9 | 10 |
Cold ischaemic time hrs.mins (range) | 16.52 | 16.45 |
(12.19-32.36) | (11.12-28.42) | |
EPO maintenance post-transplant n(%) | 9 (46%) | 11 (55%) |
Blood transfusions post-transplant (n) | 6 | 11 |
Packed red cell post-transplant (units) | 1.2 ± 0.5 | 1.9 ± 0.6 |
Acute rejection episodes in 3 mths post-transplant | 5 | 3 |