Figure 3

Co-regulation analysis among 6 potential internal control genes (ICGs). The network analysis of potential co-regulation among 6 ICGs was performed with Ingenuity Pathway Analysis (IPA). Solid lines indicate direct interactions and dotted lines indirect interactions. Edge labels indicate effects on gene expression (E), protein-DNA interactions (PD), effect on transcription (T) and protein-protein interactions (PP). Arrows indicate the direction of the effect. ICGs: HPRT1 (hypoxanthine phosphoribosyltransferase), PPIA (peptidylprolyl isomerase A), 18S (18S ribosomal rRNA), ACTB (beta actin), RPLPO (ribosomal protein, large, P0) and TUBB (beta-tubulin). Potential co-regulators: IFNG (interferon gamma), IL4 (Interleukin 4), TNF (tumor necrosis factor), MAPT (microtubule-associated protein tau), PSEN1 (presenilin 1), APP (amyloid bet (A4) precursor protein), FOS (FBJ murine osteosarcoma viral), MYCN (v-myc cytelomatosis viral oncogene homolog), MYC (v-myx cytelomatosis viral), SRF (serum response factor), NFE2L2 (nuclear factor-like 2), GTF2B (general transcription factor IIB), MBD2 (methyl-CpG binding domain protein 2), MECP2 (methyl CpG binding protein 2), TP53 (tumor protein p53).