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Table 2 Infarct size (IS) results at 1.5T by quantification method and corresponding reproducibilities

From: Comparison of semi-automated methods to quantify infarct size and area at risk by cardiovascular magnetic resonance imaging at 1.5T and 3.0T field strengths

1.5T

IS (FWHM)

IS (5SD)

IS (6SD)

IS (7SD)

IS (8SD)

IS (OAT)

IS (MANUAL)

Mean IS (%LVM)

18.3 ± 10.7

25.9 ± 16.1b

22.0 ± 15.8a

19.8 ± 15.3

17.7 ± 14.4

28.2 ± 11.8b

16.5 ± 10.3

ICC v Manual

0.909

0.667

0.759

0.804

0.832

0.621

 

Mean bias v Manual (±1.96SD LoA)

+1.84 (+10.30, −6.62)

+9.39 (+25.58, −6.81)

+5.57 (+21.65, −10.52)

+3.28 (+18.86, −12.30)

+1.21 (+15.92, −13.50)

+11.71 (+17.39, +6.03)

 

Interobserver ICC

0.922

0.952

0.904

0.906

0.888

0.976

0.793

Interobserver mean bias (±1.96SD LoA)

+0.37 (+9.17, −8.43)

+2.54 (+11.62, −6.54)

+4.43 (+16.01, −7.16)

+4.00 (+15.48, −7.47)

+4.01 (+16.02, −8.01)

+0.55 (+5.82, −4.73)

+5.34 (+14.96, −4.28)

Intraobserver ICC

0.991

0.957

0.954

0.938

0.925

0.991

0.983

Intraobserver mean bias (±1.96SD LoA)

+0.36 (+3.34, −2.61)

−0.81 (+9.37, −10.99)

+0.01 (+10.28, −10.27)

+0.07 (+11.76, −11.62)

+0.42 (+13.00, −12.17)

+0.81 (+4.21, −2.50)

−1.92 (+0.64, −4.49)

  1. IS expressed as mean ± standard deviation. FWHM = full-width half maximum, 5-8SD = >5-8 standard deviation, OAT = Otsu’s Automated Thresholding, LVM = Left Ventricular Mass, ICC = Intraclass Correlation Coefficient, LoA = Limits of Agreement (Bland-Altman).
  2. a - p < 0.05 vs. manually quantified IS. b – p < 0.01 vs. manually quantified IS.