Figure 4
Biopsy of swollen lymph nodes in the right supraclavicular fossa. Hematoxylin and eosin staining showed (a) the disappearance of follicle structure, and (b) dispersed Hodgkin-like large cells with small lymphocytes. (c)-(e) Immunostaining for CD30, Bob1 and Oct2 showed positive large cells. (f) In situ hybridization showed Epstein-Barr virus encoded ribonucleic acid in the nuclei of lymphoma cells.