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Table 3 Suggestive and significant evidence for QTLs: effect of various covariates a

From: Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results

 

P values

P values one-way ANCOVA a

 

Student’s t test (unadjusted results) a,d

Donor or consomic strain

Covariate 1: Body weight at arrival (g) b

Covariate 2: Age at blood sampling (days) b

Covariate 3: Blood collection period (day of the year) b,e

Covariate 4: Time of the day blood was collected (h) b

Covariates 1 + 2 + 3 + 4 c

A/J

†0.000 f,S

†0.000 f (0.493)

†0.000 f (0.062)

†0.000 f (0.094)

†0.000 f (0.938)

†0.004 f (0.674/0.361/0.774/0.865)

CSS-1

*0.000 S

*0.000 (0.634)

*0.000 ($0.009)

*0.002 ($0.042)

*0.000 (0.233)

*0.001 (0.963/0.146/0.808/0.219)

CSS-2

0.529S

0.549 (0.856)

0.257 (0.104)

0.080 ($0.045)

0.566 (0.459)

0.103 (0.474/0.965/0.236/0.441)

CSS-3

0.366S

0.534 (0.531)

0.798 (0.072)

0.755 (0.094)

0.326 (0.264)

0.946 (0.881/0.656/0.621/0.222)

CSS-5

0.294W

0.075 (0.976)g,R

0.114 (0.118)R

0.433 (0.225)R

0.079 (0.916)R

0.568 (0.698/0.781/0.780/0.914)R

CSS-6

0.116W

0.083 (0.853)R

0.150 (0.229)R

0.460 (0.200)R

0.080 (0.675)R

0.483 (0.524/0.690/0.723/0.645)R

CSS-7

#0.008 S

#0.016 (0.516)

0.126 ($0.015)

0.254 (0.058)

#0.007 (0.175)

0.091 (0.433/0.061/0.358/0.070)

CSS-8

0.150S

0.151 (0.735)

#0.022 (0.055)

#0.033 (0.101)

0.173 (0.574)

#0.014 (0.914/0.495/0.843/0.308)R

CSS-9

*0.001 S

*0.004 (0.776)

#0.040 (0.158)

0.053 (0.168)

*0.001 (0.942)

0.066 (0.821/0.926/0.766/0.977)

CSS-10

0.252S

0.509 (0.715)

0.895 ($0.019)

0.871 (0.109)

0.258 (0.899)

0.783 (0.975/0.067/0.432/0.629)

CSS-11

0.847S

0.832 (0.791)

0.919 (0.299)

0.383 (0.088)

0.830 (0.883)

0.092 (0.108/0.168/$0.028/0.661)

CSS-12

0.248S

0.227 (0.658)

#0.024 ($0.029)

#0.030 ($0.046)

0.241 (0.254)

#0.029 (0.886/0.490/0.941/0.201)

CSS-13

0.956S

0.793 (0.580)

0.246 (0.075)

0.275 (0.097)

0.936 (0.469)

0.338 (0.974/0.652/0.985/0.592)

CSS-14

*0.002 S

#0.015 (0.718)

#0.032 (0.100)

0.125 (0.055)

*0.002 (0.607)

0.167 (0.340/0.432/0.175/0.646)

CSS-15

0.569W

0.924 (0.972)R

0.607 (0.236)R

0.492 (0.217)R

0.896 (0.269)R

0.681 (0.617/0.931/0.552/0.301)R

CSS-16

#0.006 S

#0.007 (0.504)

0.054 (0.381)R

0.179 (0.281)R

#0.007 (0.855)

0.355 ($0.047/0.121/$0.019/0.910)

CSS-17

#0.028 S

#0.041 (0.911)

0.410 (0.057)

0.479 (0.062)

#0.031 (0.919)

0.454 (0.301/0.788/0.354/0.969)

CSS-18

0.958S

0.954 (0.974)

0.544 (0.112)

0.180 ($0.039)

0.991 (0.180)

0.140 (0.424/0.789/0.173/0.196)

CSS-19

#0.026 S

0.118 (0.531)

0.505 ($0.022)

0.544 ($0.035)

#0.027 (0.639)

0.650 (0.698/0.347/0.764/0.375)

CSS-X

#0.021 S

#0.023 (0.938)

0.106 ($0.033)

0.401 ($0.035)

#0.026 (0.655)

0.418 (0.548/0.500/0.608/0.547)

CSS-Y

#0.035 W

#0.017 (0.973)R

0.056 (0.122)R

0.101 (0.243)R

#0.004 (0.252)R

#0.010 (0.439/0.105/0.281/0.229)

  1. aSignificant evidence (*, P < 0.004) for a QTL influencing baseline circulating total cholesterol concentration on a chromosome is indicated in bold characters, whereas suggestive evidence (#, 0.004 ≤ P < 0.05) is indicated in bold and italic. (Suggestive) evidence ($, 0.004 ≤ P < 0.05) for effect of a covariate on baseline circulating total cholesterol concentration is in italics.
  2. bIn these columns P values from the one-way ANCOVA with one covariate are shown. Within a column first P value is for the main effect (‘strain’), second P value (in parentheses) is for effect of covariate.
  3. cIn this column P values from the one-way ANCOVA with four covariates are shown. First P value is for the main effect (‘strain’). Second to fifth P value are given in parentheses: second P value is for effect of covariate ‘body weight at arrival’, third P value is for effect of covariate ‘age at blood sampling’, fourth P value is for effect of covariate ‘blood collection period’, and fifth P value is for effect of covariate ‘time of the day blood was collected’.
  4. dDonor strain significantly different from host strain (†, P < 0.004).
  5. eDay of the year: January 1 = day 1, December 31 = day 365.
  6. f S = unpaired Student’s t test; W = unpaired Student’s t test with Welch-Satterthwaite correction.
  7. g R = One-way ANCOVA after ranking of the data.