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Table 4 Quantification of the differences between C57BL/6J and consomic or A/J male mice

From: Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results

Consomic or donor strain

 

Difference in baseline circulating total cholesterol level

 

Absolute difference a

Relative difference (Cohen’s d) b

 

Unadjusted c

Adjusted d

Unadjusted c

Adjusted d

CSS-1

 

−531 e

−504

−2.61 e

−2.26

CSS-2

52

212

0.29

1.01

CSS-3

−90

9

−0.42

0.04

CSS-5

−260

−90

−1.03

−0.27

CSS-6

−299

−218

−1.38

−0.89

CSS-7

−270 e

−200

−1.30

−0.97

CSS-8

166

303

0.67

1.13 e

CSS-9

−379

−269

−1.63

−1.03

CSS-10

−122

−40

−0.53

−0.16

CSS-11

−19

246

−0.10

1.14

CSS-12

99

243

0.54

1.25

CSS-13

6

142

0.03

0.58

CSS-14

−335

−183

−1.54

−0.78

CSS-15

115

228

0.45

0.78

CSS-16

−300

127

−1.35

−0.53

CSS-17

−200

−82

−1.05

−0.4

CSS-18

5

203

0.02

0.93

CSS-19

−191

−48

−1.07

−0.25

CSS-X

−214

−95

−1.20

−0.5

CSS-Y

−815

−811

−2.41

−2.31

 

Sum:

−3582

−1081

−15.62

−3.49

A/J

 

401 f

579

1.82 f

1.13

  1. aDifference between the means for the host and consomic or donor strain.
  2. bThe Cohen’s d score is here defined as the difference between the means for the host and consomic or donor strain divided by the pooled SD.
  3. cBased on unadjusted means.
  4. dBased on means adjusted for four covariates (‘body weight at arrival’, ‘age at blood sampling’, ‘blood collection period’, and ‘time of the day blood was collected’).
  5. eWhen the difference between the host and consomic strain is associated with significant evidence (P < 0.004) for a QTL influencing baseline circulating total cholesterol concentration it is indicated in bold characters, whereas association with suggestive evidence (0.004 ≤ P < 0.05) is in italics.
  6. fThe difference between the host and donor strain is significant (P < 0.004) and is indicated in bold and italics.