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Table 5 Suggestive and significant evidence for QTLs based on mouse consomic strain surveys

From: Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results

Methodological variables

Number of chromosomes with a QTL

Chromosomes

 

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

X

Y

Reference

 

QTLs influencing the difference in circulating cholesterol level between male C57BL/6J and A/J mice

 

Normal light–dark cycle, group housing, fasted overnight (≈16-18 h), 4.8% (w/w) fat in the diet, 6–8 week old mice, retro-orbital sinus puncture, serum, anesthesia

                       

11

X

–

–

X

a

–

–

X

–

X

x

X

a

–

X

x

X

–

–

X

X

[18]

Normal light–dark cycle, individual housing, fasted for 4 hours, 6.2% (w/w) fat in the diet, 8 week old mice, retro-orbital sinus puncture plasma, anesthesia

                       

11

–

x

X

X

X

X

–

X

–

X

X

–

–

–

–

–

x

X

–

x

–

[19]

Normal light–dark cycle, group housing, fasted for 4 hours, 4.0% (w/w) fat in the diet, 22–24 week old mice, trunk blood, plasma

                       

14

–

–

–

X

x

–

x

x

x

X

x

X

x

X

X

–

–

–

x

x

X

[20]

Normal light–dark cycle, fasted for 4 hours, 35.5% (w/w) fat in the diet, 22–24 week old mice, trunk blood, plasma

                       

13

–

x

X

X

–

X

X

x

–

–

X

-

X

–

X

x

x

x

–

–

X

[20]

Reversed light–dark cycle, individual housing, non-fasted, 3.4% (w/w) fat in the diet, 6–10 week old mice, trunk blood, plasma

                       

9

X

–

–

a

–

–

x

–

X

–

–

–

–

X

–

x

x

–

x

x

x

[This study]b

4

X

–

–

a

–

–

–

x

–

–

–

x

–

–

–

–

–

–

–

–

x

[This study]c

  1. X  = significant (P < 0.004), x = suggestive (0.004 ≤ P < 0.05), and – = no evidence (P ≥ 0.05) for a circulating total cholesterol QTL on a particular chromosome.
  2. aThis consomic line was not tested.
  3. bBased on unadjusted means.
  4. cBased on means adjusted for four covariates (‘body weight at arrival’, ‘age at blood sampling’, ‘blood collection period’, and ‘time of the day blood was collected’).