Figure 2

Chest radiograph and chest CT scan before (A and B) and after (C, D, E, F and G) crizotinib treatment: (A) Chest radiograph before crizotinib therapy, (B) and swelling of the mediastinal lymph node (#4R), (C) chest radiograph after 5 days of crizotinib treatment revealing increase in pleural effusions, (D) detection of right pleural effusions due to the appearance of congestive heart failure and renal failure, (E) disappearance of pleural effusions and significant shrinking of the mediastinal lymph node. (F) CT scan just before the crizotinib re-challenge after 4 months withdrawal. (G) CT scan after 3 months of the crizotinib re-challenging treatment.