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Table 1 A sample Protein-Protein interaction network constructed in this study

From: A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components

Node A

Node B

Interaction type A- > B

UVA

Lipid_Peroxidation_kerat

induces

Lipid_Peroxidation_kerat

4HNE_kerat

increases level

4HNE_kerat

DNA_Damage_kerat

induces

DNA_Damage_kerat

TP53_kerat

activates

TP53_kerat

ACTH_kerat

increases expression

TP53_kerat

alpha_MSH_kerat

increases expression

ACTH_kerat

MC1R_melan

activates

alpha_MSH_kerat

MC1R_melan

activates

MC1R_melan

ADCY4_melan

activates

ADCY4_melan

cAMP_melan

increases level

CREB1_melan

PTGS2_melan

increases expression

PGE2_kerat

PTGER3_melan

activates

PGE2_kerat

PTGER1_melan

activates

PTGER3_melan

PLC_melan

activates

PTGER1_melan

PLC_melan

activates

PLC_melan

DAG_melan

increases level

DAG_melan

PRKCB_melan

activates

PTGS2_melan

PGE2_melan

Increases level

PRKCB_melan

TYR_melan

activates

TYR_melan

Eumelanin_melan

Increases level

  1. The complete network can be found in Additional file 1.