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Table 4 Essential nodes - Nodes are ranked according to the number of source- > target pathways they are essential in

From: A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components

Node

No: of source- > target pathways it is essential in

RAC1_melan

34

MITF_melan

29

NFKB1_kerat

25

TYR_melan

18

PLC_melan

14

PTGS2_kerat

9

CASP8_kerat

9

F2RL1_kerat

8

AKT1_melan

7

ADCY4_melan

7

CREB1_melan

4

PRKCD_kerat

2

PTGER1_melan

1

MC1R_melan

1