Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis

BMC Research Notes

Table 2 Enrichment of modules identified in the dystrophic network

Module	#Nodes	Top Term	p-value
D1	247	cytoskeleton organization	1.89E-04
D2	156	response to wounding	5.09E-07
D3	121	blood vessel development	5.07E-03
D4	377	modification-dependent macromolecule catabolic process	1.56E-03
D5	540	ubiquitin-dependent protein catabolic process	5.24E-04
D6	874	generation of precursor metabolites and energy	7.03E-30
D7	180	muscle system process	2.67E-04
D8	301	RNA splicing	3.52E-10
D9	75	extracellular matrix organization	1.22E-05
D10	1089	positive regulation of ligase activity	9.73E-05

This table represents the top functional enrichment from the highest ranking annotation cluster identified for each module of the diseased network. The annotation clusters were ranked and identified using DAVID’s annotation clustering tool [31] [see Additional file 7].

ISSN: 1756-0500