Fig. 1

Lesion size and parasitism in mouse footpads six weeks after infection. The mice were treated with saline (Saline), saline supplemented with protease inhibitors (Saline + PI), or with L. amazonensis extract in the presence (LaE + PI) or absence (LaE) of protease inhibitors, as detailed in the Materials and Methods. a Lesion sizes, measured with a digital caliper as described in the Material and Methods. b Parasite numbers per milligram of tissue, as assessed by limiting dilution. Each symbol represent the value obtained from an individual mouse. The horizontal lines represent the median values of the results. *P ≤ 0.05; **P ≤ 0.01 (Kruskal-Wallis’s test followed by Dunn’s post test)