TY - JOUR AU - Marur, S. AU - Forastiere, A. A. PY - 2008 DA - 2008// TI - Head and neck cancer: changing epidemiology, diagnosis, and treatment JO - Mayo Clin Proc VL - 83 UR - https://doi.org/10.4065/83.4.489 DO - 10.4065/83.4.489 ID - Marur2008 ER - TY - JOUR AU - Rubin Grandis, J. AU - Melhem, M. F. AU - Gooding, W. E. AU - Day, R. AU - Holst, V. A. AU - Wagener, M. M. PY - 1998 DA - 1998// TI - Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival JO - J Nat Cancer Inst VL - 90 UR - https://doi.org/10.1093/jnci/90.11.824 DO - 10.1093/jnci/90.11.824 ID - Rubin Grandis1998 ER - TY - JOUR AU - Grandis, J. R. AU - Sok, J. C. PY - 2004 DA - 2004// TI - Signaling through the epidermal growth factor receptor during the development of malignancy JO - Pharmacol Ther VL - 102 UR - https://doi.org/10.1016/j.pharmthera.2004.01.002 DO - 10.1016/j.pharmthera.2004.01.002 ID - Grandis2004 ER - TY - JOUR AU - Mrhalova, M. AU - Plzak, J. AU - Betka, J. AU - Kodet, R. PY - 2005 DA - 2005// TI - Epidermal growth factor receptor—its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas JO - Neoplasma VL - 52 ID - Mrhalova2005 ER - TY - JOUR AU - Cunningham, D. AU - Humblet, Y. AU - Siena, S. AU - Khayat, D. AU - Bleiberg, H. AU - Santoro, A. PY - 2004 DA - 2004// TI - Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer JO - N Engl J Med VL - 351 UR - https://doi.org/10.1056/NEJMoa033025 DO - 10.1056/NEJMoa033025 ID - Cunningham2004 ER - TY - JOUR AU - Bonner, J. A. AU - Harari, P. M. AU - Giralt, J. AU - Azarnia, N. AU - Shin, D. M. AU - Cohen, R. B. PY - 2006 DA - 2006// TI - Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck JO - N Engl J Med VL - 354 UR - https://doi.org/10.1056/NEJMoa053422 DO - 10.1056/NEJMoa053422 ID - Bonner2006 ER - TY - JOUR AU - Vermorken, J. B. AU - Trigo, J. AU - Hitt, R. AU - Koralewski, P. AU - Diaz-Rubio, E. AU - Rolland, F. PY - 2007 DA - 2007// TI - Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy JO - J Clin Oncol VL - 25 UR - https://doi.org/10.1200/JCO.2006.06.7447 DO - 10.1200/JCO.2006.06.7447 ID - Vermorken2007 ER - TY - JOUR AU - Boeckx, C. AU - Baay, M. AU - Wouters, A. AU - Specenier, P. AU - Vermorken, J. B. AU - Peeters, M. PY - 2013 DA - 2013// TI - Anti-epidermal growth factor receptor therapy in head and neck squamous cell carcinoma: focus on potential molecular mechanisms of drug resistance JO - Oncologist VL - 18 UR - https://doi.org/10.1634/theoncologist.2013-0013 DO - 10.1634/theoncologist.2013-0013 ID - Boeckx2013 ER - TY - JOUR AU - Brizel, D. M. AU - Dodge, R. K. AU - Clough, R. W. AU - Dewhirst, M. W. PY - 1999 DA - 1999// TI - Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome JO - Radiother Oncol VL - 53 UR - https://doi.org/10.1016/S0167-8140(99)00102-4 DO - 10.1016/S0167-8140(99)00102-4 ID - Brizel1999 ER - TY - JOUR AU - Gabalski, E. C. AU - Adam, M. AU - Pinto, H. AU - Brown, J. M. AU - Bloch, D. A. AU - Terris, D. J. PY - 1998 DA - 1998// TI - Pretreatment and midtreatment measurement of oxygen tension levels in head and neck cancers JO - Laryngoscope VL - 108 UR - https://doi.org/10.1097/00005537-199812000-00017 DO - 10.1097/00005537-199812000-00017 ID - Gabalski1998 ER - TY - JOUR AU - Dunst, J. AU - Stadler, P. AU - Becker, A. AU - Lautenschlager, C. AU - Pelz, T. AU - Hansgen, G. PY - 2003 DA - 2003// TI - Tumor volume and tumor hypoxia in head and neck cancers. The amount of the hypoxic volume is important JO - Strahlenther Onkol VL - 179 UR - https://doi.org/10.1007/s00066-003-1066-4 DO - 10.1007/s00066-003-1066-4 ID - Dunst2003 ER - TY - JOUR AU - Hoogsteen, I. J. AU - Marres, H. A. AU - Hoogen, F. J. AU - Rijken, P. F. AU - Lok, J. AU - Bussink, J. PY - 2012 DA - 2012// TI - Expression of EGFR under tumor hypoxia: identification of a subpopulation of tumor cells responsible for aggressiveness and treatment resistance JO - Int J Radiat Oncol Biol Phys VL - 84 UR - https://doi.org/10.1016/j.ijrobp.2012.01.002 DO - 10.1016/j.ijrobp.2012.01.002 ID - Hoogsteen2012 ER - TY - JOUR AU - Laderoute, K. R. AU - Grant, T. D. AU - Murphy, B. J. AU - Sutherland, R. M. PY - 1992 DA - 1992// TI - Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen JO - Int J Cancer VL - 52 UR - https://doi.org/10.1002/ijc.2910520317 DO - 10.1002/ijc.2910520317 ID - Laderoute1992 ER - TY - JOUR AU - Krause, M. AU - Ostermann, G. AU - Petersen, C. AU - Yaromina, A. AU - Hessel, F. AU - Harstrick, A. PY - 2005 DA - 2005// TI - Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation JO - Radiother Oncol VL - 76 UR - https://doi.org/10.1016/j.radonc.2005.06.032 DO - 10.1016/j.radonc.2005.06.032 ID - Krause2005 ER - TY - JOUR AU - Swinson, D. E. AU - O’Byrne, K. J. PY - 2006 DA - 2006// TI - Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer JO - Clin Lung Cancer VL - 7 UR - https://doi.org/10.3816/CLC.2006.n.002 DO - 10.3816/CLC.2006.n.002 ID - Swinson2006 ER - TY - JOUR AU - Semenza, G. L. AU - Agani, F. AU - Feldser, D. AU - Iyer, N. AU - Kotch, L. AU - Laughner, E. PY - 2000 DA - 2000// TI - Hypoxia, HIF-1, and the pathophysiology of common human diseases JO - Adv Exp Med Biol VL - 475 ID - Semenza2000 ER - TY - JOUR AU - Franovic, A. AU - Gunaratnam, L. AU - Smith, K. AU - Robert, I. AU - Patten, D. AU - Lee, S. PY - 2007 DA - 2007// TI - Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer JO - Proc Natl Acad Sci USA VL - 104 UR - https://doi.org/10.1073/pnas.0702387104 DO - 10.1073/pnas.0702387104 ID - Franovic2007 ER - TY - JOUR AU - Misra, A. AU - Pandey, C. AU - Sze, S. K. AU - Thanabalu, T. PY - 2012 DA - 2012// TI - Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT) JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0049766 DO - 10.1371/journal.pone.0049766 ID - Misra2012 ER - TY - JOUR AU - Stegeman, H. AU - Kaanders, J. H. AU - Wheeler, D. L. AU - Kogel, A. J. AU - Verheijen, M. M. AU - Waaijer, S. J. PY - 2012 DA - 2012// TI - Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck JO - BMC Cancer VL - 12 UR - https://doi.org/10.1186/1471-2407-12-463 DO - 10.1186/1471-2407-12-463 ID - Stegeman2012 ER - TY - JOUR AU - Wouters, A. AU - Boeckx, C. AU - Vermorken, J. B. AU - Weyngaert, D. AU - Peeters, M. AU - Lardon, F. PY - 2013 DA - 2013// TI - The intriguing interplay between therapies targeting the epidermal growth factor receptor, the hypoxic microenvironment and hypoxia-inducible factors JO - Curr Pharm Des VL - 19 UR - https://doi.org/10.2174/138161213804547259 DO - 10.2174/138161213804547259 ID - Wouters2013 ER - TY - JOUR AU - Wouters, A. AU - Pauwels, B. AU - Burrows, N. AU - Baay, M. AU - Deschoolmeester, V. AU - Vu, T. N. PY - 2014 DA - 2014// TI - The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein JO - BMC Cancer VL - 14 UR - https://doi.org/10.1186/1471-2407-14-594 DO - 10.1186/1471-2407-14-594 ID - Wouters2014 ER - TY - JOUR AU - Wouters, A. AU - Pauwels, B. AU - Lambrechts, H. A. AU - Pattyn, G. G. AU - Ides, J. AU - Baay, M. PY - 2009 DA - 2009// TI - Chemoradiation interactions under reduced oxygen conditions: cellular characteristics of an in vitro model JO - Cancer Lett VL - 286 UR - https://doi.org/10.1016/j.canlet.2009.05.026 DO - 10.1016/j.canlet.2009.05.026 ID - Wouters2009 ER - TY - JOUR AU - Pauwels, B. AU - Korst, A. E. AU - Pooter, C. M. AU - Pattyn, G. G. AU - Lambrechts, H. A. AU - Baay, M. F. PY - 2003 DA - 2003// TI - Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies JO - Cancer Chemother Pharmacol VL - 51 ID - Pauwels2003 ER - TY - JOUR AU - Damme, N. AU - Deron, P. AU - Roy, N. AU - Demetter, P. AU - Bols, A. AU - Dorpe, J. PY - 2010 DA - 2010// TI - Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas JO - BMC Cancer VL - 10 UR - https://doi.org/10.1186/1471-2407-10-189 DO - 10.1186/1471-2407-10-189 ID - Damme2010 ER - TY - JOUR AU - Szabo, B. AU - Nelhubel, G. A. AU - Karpati, A. AU - Kenessey, I. AU - Jori, B. AU - Szekely, C. PY - 2011 DA - 2011// TI - Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas JO - Oral Oncol VL - 47 UR - https://doi.org/10.1016/j.oraloncology.2011.03.020 DO - 10.1016/j.oraloncology.2011.03.020 ID - Szabo2011 ER - TY - JOUR AU - Byers, L. A. AU - Holsinger, F. C. AU - Kies, M. S. AU - William, W. N. AU - El-Naggar, A. K. AU - Lee, J. J. PY - 2010 DA - 2010// TI - Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer JO - Mol Cancer Ther VL - 9 UR - https://doi.org/10.1158/1535-7163.MCT-09-1047 DO - 10.1158/1535-7163.MCT-09-1047 ID - Byers2010 ER - TY - JOUR AU - Luwor, R. B. AU - Lu, Y. AU - Li, X. AU - Mendelsohn, J. AU - Fan, Z. PY - 2005 DA - 2005// TI - The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression JO - Oncogene VL - 24 UR - https://doi.org/10.1038/sj.onc.1208625 DO - 10.1038/sj.onc.1208625 ID - Luwor2005 ER - TY - JOUR AU - Li, X. AU - Lu, Y. AU - Liang, K. AU - Pan, T. AU - Mendelsohn, J. AU - Fan, Z. PY - 2008 DA - 2008// TI - Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab JO - Mol Cancer Ther VL - 7 UR - https://doi.org/10.1158/1535-7163.MCT-07-2187 DO - 10.1158/1535-7163.MCT-07-2187 ID - Li2008 ER - TY - JOUR AU - Lee, C. M. AU - Tannock, I. F. PY - 2010 DA - 2010// TI - The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors JO - BMC Cancer VL - 10 UR - https://doi.org/10.1186/1471-2407-10-255 DO - 10.1186/1471-2407-10-255 ID - Lee2010 ER - TY - JOUR AU - Riesterer, O. AU - Mason, K. A. AU - Raju, U. AU - Yang, Q. AU - Wang, L. AU - Hittelman, W. N. PY - 2009 DA - 2009// TI - Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bed JO - Radiother Oncol VL - 92 UR - https://doi.org/10.1016/j.radonc.2009.07.009 DO - 10.1016/j.radonc.2009.07.009 ID - Riesterer2009 ER - TY - JOUR AU - Cerniglia, G. J. AU - Pore, N. AU - Tsai, J. H. AU - Schultz, S. AU - Mick, R. AU - Choe, R. PY - 2009 DA - 2009// TI - Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0006539 DO - 10.1371/journal.pone.0006539 ID - Cerniglia2009 ER - TY - JOUR AU - Riesterer, O. AU - Yang, Q. AU - Raju, U. AU - Torres, M. AU - Molkentine, D. AU - Patel, N. PY - 2011 DA - 2011// TI - Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers JO - Int J Radiat Oncol Biol Phys VL - 79 UR - https://doi.org/10.1016/j.ijrobp.2010.10.003 DO - 10.1016/j.ijrobp.2010.10.003 ID - Riesterer2011 ER - TY - JOUR AU - Li, X. AU - Fan, Z. PY - 2010 DA - 2010// TI - The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-10-0157 DO - 10.1158/0008-5472.CAN-10-0157 ID - Li2010 ER - TY - JOUR AU - Lu, H. AU - Liang, K. AU - Lu, Y. AU - Fan, Z. PY - 2012 DA - 2012// TI - The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1alpha JO - Cancer Lett VL - 322 UR - https://doi.org/10.1016/j.canlet.2012.02.012 DO - 10.1016/j.canlet.2012.02.012 ID - Lu2012 ER - TY - JOUR AU - Huang, S. M. AU - Harari, P. M. PY - 2000 DA - 2000// TI - Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis JO - Clin Cancer Res VL - 6 ID - Huang2000 ER - TY - JOUR AU - Perrotte, P. AU - Matsumoto, T. AU - Inoue, K. AU - Kuniyasu, H. AU - Eve, B. Y. AU - Hicklin, D. J. PY - 1999 DA - 1999// TI - Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice JO - Clin Cancer Res VL - 5 ID - Perrotte1999 ER - TY - JOUR AU - Hirata, A. AU - Ogawa, S. AU - Kometani, T. AU - Kuwano, T. AU - Naito, S. AU - Kuwano, M. PY - 2002 DA - 2002// TI - ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase JO - Cancer Res VL - 62 ID - Hirata2002 ER - TY - JOUR AU - Pore, N. AU - Jiang, Z. AU - Gupta, A. AU - Cerniglia, G. AU - Kao, G. D. AU - Maity, A. PY - 2006 DA - 2006// TI - EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-3090 DO - 10.1158/0008-5472.CAN-05-3090 ID - Pore2006 ER - TY - JOUR AU - Rho, J. K. AU - Choi, Y. J. AU - Lee, J. K. AU - Ryoo, B. Y. AU - Na, I. I. AU - Yang, S. H. PY - 2009 DA - 2009// TI - Gefitinib circumvents hypoxia-induced drug resistance by the modulation of HIF-1alpha JO - Oncology Rep VL - 21 ID - Rho2009 ER - TY - JOUR AU - Luo, H. Y. AU - Wei, W. AU - Shi, Y. X. AU - Chen, X. Q. AU - Li, Y. H. AU - Wang, F. PY - 2010 DA - 2010// TI - Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines JO - Oncol Rep VL - 23 ID - Luo2010 ER - TY - JOUR AU - Huang, S. M. AU - Li, J. AU - Armstrong, E. A. AU - Harari, P. M. PY - 2002 DA - 2002// TI - Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa) JO - Cancer Res VL - 62 ID - Huang2002 ER -