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Table 2 HLA-B27 variants associated with cocaine-associated agranulocytosis

From: Genetic determinants of cocaine-associated agranulocytosis

SNP haplotype Cases (N = 8) Controls (N = 26) Odds ratio (95% CI) P value
HLA-B27    9.2 (1.54–54.6) 0.017
 +, no. (%) 5 (62.5) 4 (15.4)   
 −, no. (%) 3 (37.5) 22 (84.6)   
rs4349859—dominant model    9.2 (1.54–54.6) 0.017
 A_, no. (%) 5 (62.5) 4 (15.4)   
 GG, no. (%) 3 (37.5) 22 (84.6)   
rs4349859—additive genetic model     0.017
 AA, no. (%) 1 (12.5) 0   
 AG, no. (%) 4 (50) 4 (15.4)   
 GG, no. (%) 3 (37.5) 22 (84.6)   
rs13202464—dominant model    6.8 (1.11–41.0) 0.042
 G_, no. (%) 6 (75) 8 (30.8)   
 AA, no. (%) 2 (25) 18 (69.2)   
rs13202464—additive genetic model     0.011
 GG, no. (%) 2 (25) 0   
 AG, no. (%) 4 (50) 8 (30.8)   
 AA, no. (%) 2 (25) 18 (69.2)   
  1. SNP single nucleotide polymorphism, CI confidence intervals.
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