Table 2 Quartile of baseline serum vitamin B12 levels with regard to host and viral factors and treatment response
Characteristics | <340 (n = 27) | 340–488 (n = 27) | 488–727 (n = 26) | >727 (n = 27) | P value |
|---|---|---|---|---|---|
Male sex n (%) | 19 (70%) | 20 (74%) | 13 (50%) | 13 (48%) | 0.29 |
Age [median (range)] | 47 (23–77) | 53 (22–70) | 51 (32–73) | 51 (23–71) | 0.74 |
HCV subtype n (%) | |||||
 1a | 8 (29%) | 12 (44%) | 7 (27%) | 6 (22%) | 0.55 |
 1b | 18 (67%) | 15 (56%) | 18 (69%) | 19 (70%) | |
 1a + b | 1 (4%) | 0 | 1 (4%) | 2 (8%) | |
RVR n (%) | 19 (70%) | 12 (44%) | 9 (35%) | 5 (19%) | 0.001 |
SVR n (%) | 22 (81%) | 12 (44%) | 7 (27%) | 2 (7%) | <0.001 |
AST [median (IQR)] U/L | 39 (30–54) | 42 (32–51) | 45 (36–77) | 73 (53–121) | 0.002 |
ALT [median (IQR)] U/L | 46 (24–94) | 44 (27–64) | 55 (36–85) | 66 (49–150) | 0.04 |
γ-GT [median (IQR)] U/L | 38 (28–87) | 52 (24–103) | 63 (41–136) | 68 (28–142) | 0.12 |
Hepatitis activity n (%) | |||||
 Mild | 21 (78%) | 18 (67%) | 19 (73%) | 15 (56%) | 0.58 |
 Moderate/severe | 6 (22%) | 9 (33%) | 7 (27%) | 12 (44%) | |
Fibrosis n (%) | |||||
 Absent/mild/moderate | 26 (96%) | 22 (81%) | 22 (85%) | 11 (41%) | 0.0001 |
 Severe/cirrhosis | 1 (4%) | 5 (19%) | 4 (15%) | 16 (59%) | |
Steatosis | |||||
 0–5% | 21 (78%) | 19 (70%) | 19 (73%) | 15 (56%) | 0.26 |
 6–100% | 6 (22%) | 7 (26%) | 7 (27%) | 12 (44%) | |
 Missing | 0 | 1 (4%) | 0 | 0 | |
IFNL3/IFNL4 rs12979860 n (%) | |||||
 CC | 16 (59%) | 11 (41%) | 5 (19%) | 9 (33%) | 0.04 |
 CT | 8 (30%) | 15 (55%) | 15 (58%) | 12 (44%) | 8 (30%) |
 TT | 2 (7%) | 1 (4%) | 5 (19%) | 5 (19%) | 2 (7%) |
 Missing | 1 (4%) | 0 | 1 (4%) | 1 (4%) | 1 (4%) |