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Table 3 Uni- and multivariate analysis of factors associated with treatment response

From: Association of serum vitamin B12 levels with stage of liver fibrosis and treatment outcome in patients with chronic hepatitis C virus genotype 1 infection: a retrospective study

Characteristics Univariate analysis Multivariate analysis
  P value P value
Male sex n (%) 68 (59%) 0.07 0.19
Age [median (range)] 51 (22–80) 0.28  
RVR n (%) 40 (82%) <0.001 <0.001
Vitamin B12 [median (IQR)] ng/L 488 (339–727) <0.001 <0.001
HCV-RNA level [median (IQR)] copies/mL 1.8 × 106 (4.5 × 105–6.2 × 106) <0.001 <0.05
IFNL3/IFNL4 rs12979860 CC n (%) 28 (64%) 0.0001 <0.001
Hepatitis activity n (%)
 Mild 79 (68%) 0.70  
Fibrosis n (%)
 Absent/mild/moderate 89 (77%) 0.01 <0.05
Steatosis n (%)
 0–5% 58 (50%) 0.02 0.01
  1. RVR rapid virological response.
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