Association of serum vitamin B12 levels with stage of liver fibrosis and treatment outcome in patients with chronic hepatitis C virus genotype 1 infection: a retrospective study

Table 3 Uni- and multivariate analysis of factors associated with treatment response

Characteristics	Univariate analysis		Multivariate analysis
Characteristics		P value	P value
Male sex n (%)	68 (59%)	0.07	0.19
Age [median (range)]	51 (22–80)	0.28
RVR n (%)	40 (82%)	<0.001	<0.001
Vitamin B₁₂ [median (IQR)] ng/L	488 (339–727)	<0.001	<0.001
HCV-RNA level [median (IQR)] copies/mL	1.8 × 10⁶ (4.5 × 10⁵–6.2 × 10⁶)	<0.001	<0.05
IFNL3/IFNL4 rs12979860 CC n (%)	28 (64%)	0.0001	<0.001
Hepatitis activity n (%)
Mild	79 (68%)	0.70
Fibrosis n (%)
Absent/mild/moderate	89 (77%)	0.01	<0.05
Steatosis n (%)
0–5%	58 (50%)	0.02	0.01

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