Table 1 Baseline characteristics of patients included in the qPCR and the SNP genotyped cohorts
From: Mitochondrial DNA polymorphisms, its copy number change and outcome in colorectal cancer
Variables | qPCR cohort | Polymorphism cohort |
|---|---|---|
n (%) | n (%) | |
Sex | ||
Female | 116 (42.03) | 208 (38.81) |
Male | 160 (57.97) | 328 (61.19) |
Location | ||
Colon | 183 (66.3) | 355 (66.23) |
Rectum | 93 (33.7) | 181 (33.77) |
Histology | ||
Non-mucinous | 243 (88.04) | 475 (88.62) |
Mucinous | 33 (11.96) | 61 (11.38) |
Stage | ||
I | 31 (11.23) | 98 (18.28) |
II | 94 (34.06) | 207 (39.62) |
III | 101 (36.6) | 178 (33.21) |
IV | 50 (18.11) | 53 (9.89) |
Grade | ||
Well/moderately differentiated | 243 (88.04) | 493 (91.98) |
Poorly differentiated/undifferentiated | 32 (11.6) | 39 (7.28) |
Unknown | 1 (0.36) | 4 (0.75) |
Vascular invasion | ||
− | 139 (50.36) | 326 (60.82) |
+ | 111 (40.22) | 171 (31.9) |
Unknown | 26 (9.42) | 39 (7.28) |
Lymphatic invasion | ||
− | 137 (49.64) | 315 (58.77) |
+ | 113 (40.94) | 179 (33.4) |
Unknown | 26 (9.42) | 42 (7.84) |
Familial risk | ||
Low | 142 (51.45) | 256 (47.76) |
High/intermediate | 133 (48.19) | 280 (52.24) |
Unknown | 1 (0.36) | |
MSI status | ||
MSI-L/MSS | 248 (89.86) | 456 (85.07) |
MSI-H | 26 (9.42) | 58 (10.82) |
Unknown | 2 (0.72) | 22 (4.1) |
BRAF1 Val600Glu mutation | ||
− | 219 (79.35) | 436 (81.34) |
+ | 35 (12.68) | 49 (9.14) |
Unknown | 22 (7.97) | 51 (9.51) |
OS status | ||
Alive | 141 (51.09) | 353 (65.86) |
Dead | 134 (48.55) | 182 (33.96) |
Unknown | 1 (0.36) | 1 (0.19) |
Median OS follow-up | 6.2 years (range 0.036–10.88) | 6.3 years (range 0.38–10.88) |
DFS status | ||
Recurrence/metastasis/death (−) | 126 (45.65) | 322 (60.07) |
Recurrence/metastasis/death (+) | 149 (53.99) | 213 (39.74) |
Unknown | 1 (0.36) | 1 (0.19) |
Median DFS follow-up | 5.1 years (range 0.036–10.88) | 5.98 years (range 0.22–10.88) |
Median age | 62.4 years (range 31.75–74.94) | 61.3 years (range 20.7–74.98) |