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Table 3 Factors associated with clinical events

From: Assessment of adverse events via a telephone consultation service for cancer patients receiving ambulatory chemotherapy

Characteristics Event 1: change of schedule Event 2: change in therapy
All grades Hazard ratio 95% CI P Hazard ratio 95% CI P
Univariate analyses
 Age
  ≤64 vs. ≥65 1.08 0.66–1.73 0.77 0.66 0.39–1.13 0.13
 Sex
  Male vs. female 1.71 0.99–2.96 >0.05 3.07 1.70–5.52 <0.001
 Consulter
  Patients vs. caregiver 0.47 0.22–1.01 >0.05 0.38 0.17–0.84 <0.05
 Cancer type
  Breast cancer 0.85 0.54–1.33 0.47 0.55 0.32–0.93 0.03
  Pancreatic cancer 1.44 0.76–2.73 0.27 2.14 1.08–4.23 0.03
  Ovarian cancer 0.84 0.36–1.97 0.69 0.63 0.21–1.88 0.41
  Colorectal cancer 0.56 0.22–1.41 0.22 0.84 0.31–2.29 0.73
  Soft tissue sarcoma 1.87 0.61–5.70 0.27 1.18 0.32–4.42 0.80
  Gastric cancer 0.91 0.23–3.59 0.89 2.71 0.74–9.87 0.13
  Biliary tract cancer 1.28 0.30–5.47 0.74 1.31 0.26–6.65 0.74
  Liver cancer 0.85 0.16–4.44 0.85 3.02 0.66–13.83 0.15
  Malignant lymphoma 4.34 0.79–24.27 0.09 0.78 0.09–6.78 0.82
  Primary unknown cancer 0.53 0.06–4.78 0.57 0.98 0.11–8.89 0.98
  Endometrial cancer 1.43 0.24–8.67 0.70 2.66 0.44–16.22 0.29
 Objective of therapy
  Adjuvant chemotherapy 0.70 0.51–0.95 <0.05 0.45 0.31–0.65 <0.001
  Palliative chemotherapy 1.05 0.84–1.33 0.65 1.57 1.20–2.05 0.001
  Chemotherapy for blood malignancy 0.23 0.04–1.27 0.09 1.28 0.14–11.16 0.82
Grading of adverse event
  Grade 2 + grade 3 vs. grade 1 6.70 4.06–11.05 <0.001 6.55 3.67–11.67 <0.001
  Grade 3 vs. grade 1 + grade 2 0.38 0.18–0.78 <0.01 0.33 0.15–0.70 <0.01
Multivariate analyses
 Sex
  Male vs. female     2.70 1.15–6.30 0.02
 Consulter
  Patients vs. caregiver     1.65 0.67–4.06 0.28
 Cancer type
  Breast cancer     0.80 0.36–1.77 0.58
  Pancreatic cancer     0.58 0.21–1.31 0.17
 Objective of therapy
  Adjuvant chemotherapy 0.96 0.69–1.33 0.78 0.77 0.52–1.15 0.20
 Grading of adverse event
  Grade 2 + grade 3 vs. grade 1 6.58 3.93–11.02 <0.001 6.25 3.31–11.80 <0.001