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Table 3 Power and false positive rates of Chi8 and GBOOST on simulated GWAS of 1600 subjects

From: Chi8: a GPU program for detecting significant interacting SNPs with the Chi-square 8-df test

Allele freq.

0.1

0.2

0.4

Model 1

 Chi8

0.22 (0.02)

0.04 (0)

0 (0)

 GBOOST

0.45 (0.12)

0.37 (0.08)

0.09 (0.05)

Model 2

 Chi8

0.22 (0.01)

0.94 (0.02)

0.91 (0.01)

 GBOOST

0.32 (0.09)

0.98 (0.04)

0.98 (0.1)

Model 3

 Chi8

0.25 (0.02)

0.36 (0.02)

0.77 (0)

 GBOOST

0.23 (0.11)

0.49 (0.11)

0.96 (0.06)

Model 4

 Chi8

0.09 (0)

0.73 (0.02)

1 (0.02)

 GBOOST

0.29 (0.08)

0.98 (0.13)

0.98 (0.18)

  1. To account for Chi8’s sensitivity to univariate significant SNPs we only consider reported pairs where both SNPs are also individually insignificant