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Table 4 Mean area under curve of Chi8 and GBOOST on simulated GWAS of 800 subjects

From: Chi8: a GPU program for detecting significant interacting SNPs with the Chi-square 8-df test

Allele freq. 0.1 0.2 0.4
Model 1
 Chi8 0.4 0.41 0.32
 GBOOST 0.1 0.1 0.07
Model 2
 Chi8 0.68 0.88 0.85
 GBOOST 0.08 0.64 0.68
Model 3
 Chi8 0.45 0.54 0.81
 GBOOST 0.09 0.14 0.62
Model 4
 Chi8 0.64 0.84 0.86
 GBOOST 0.09 0.54 0.86
  1. To account for Chi8’s sensitivity to univariate significant SNPs we only consider reported pairs where both SNPs are also individually insignificant