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Table 2 Average relative risk increase due to specific risk factor for each included risk calculator among non-diabetic patients (relative risk increase ± standard deviation)

From: Variation among cardiovascular risk calculators in relative risk increases with identical risk factor increases

Risk calculator

Age (50–70) (%)

Gender (female to male) (%)

Smoking (non-smoker to smoker) (%)

Systolic BP (120–160 mmHg) (%)

Total chol (4–7 mmol/L) (%)

HDL (1.3–0.8 mmol/L) (%)

Edinburgh (Framingham CVD)

112 ± 35

44 ± 12

70 ± 24

73 ± 25

51 ± 17

42 ± 14

Edinburgh (ASSIGN)

222 ± 53

35 ± 28

37 ± 8

49 ± 6

60 ± 21

27 ± 3

Primary CVD risk calculator

103 ± 31

56 ± 18

59 ± 15

69 ± 17

66 ± 20

56 ± 19

Framingham Heart Study

121 ± 23

91 ± 33

67 ± 11

83 ± 26

78 ± 13

41 ± 7

QRISK2-2011

335 ± 91

53 ± 20

57 ± 20

30 ± 17

51 ± 15

43 ± 14

Progetto CUORE

313 ± 30

141 ± 57

87 ± 27

75 ± 13

66 ± 26

29 ± 4

JBS Assessor

110 ± 35

48 ± 16

59 ± 15

43 ± 13

63 ± 19

54 ± 18

Edinburgh (BNF)

105 ± 31

56 ± 18

59 ± 13

71 ± 19

68 ± 22

56 ± 18

Reynolds Risk Score

344 ± 96

119 ± 82

83 ± 50

124 ± 44

89 ± 42

60 ± 35

Australian absolute CVD risk

153 ± 50

61 ± 20

95 ± 38

98 ± 37

65 ± 20

55 ± 19

New Zealand Know Your Numbers

154 ± 49

60 ± 19

95 ± 37

99 ± 37

60 ± 22

50 ± 21

UKPDS Risk Engine

182 ± 16

79 ± 8

31 ± 3

16 ± 2

77 ± 8

64 ± 6

i-phone STAT ATPIII lipid management

210 ± 228

225 ± 140

116 ± 110

72 ± 32

154 ± 124

61 ± 14

Edinburgh (Framingham CHD)

82 ± 32

64 ± 26

55 ± 16

51 ± 5

88 ± 26

73 ± 22

PROCAM Health Check

395 ± 204

114 ± 82

118 ± 27

35 ± 8

302 ± 67

133 ± 30

National Cholesterol Education Program

198 ± 203

201 ± 124

110 ± 125

69 ± 49

141 ± 129

61 ± 33

Overall average

196 ± 140

91 ± 80

75 ± 54

66 ± 37

92 ± 80

57 ± 30