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Fig. 3 | BMC Research Notes

Fig. 3

From: Tools for translational epigenetic studies involving formalin-fixed paraffin-embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population-based studies

Fig. 3

Probe mean beta values at the BRCA1 gene. a Mean beta values measured from 419 tumour-enriched DNA in our dataset. Twenty probes overlapping exon 1 of BRCA1, exon 1 of NBR2 and their shared bi-directional promoter showed increased methylation in triple-negative breast cancers (TNBC) compared with Luminal A (Lum A), Luminal B (Lum B) and HER2-positive (HER2-pos) subtypes (* denotes probes not present in the TCGA dataset). b Mean beta values measured from 156 tumour-enriched DNA in TCGA. Twenty-two probes overlapping exon 1 of BRCA1, exon 1 of NBR2 and their shared bi-directional promoter showed increased methylation in basal-like breast cancers (TNBC) compared with Luminal A (Lum A), Luminal B (Lum B) and HER2-enriched (HER2-pos) subtypes (+ denotes probes not present in our dataset)

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BMC Research Notes

ISSN: 1756-0500

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