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Fig. 4 | BMC Research Notes

Fig. 4

From: Bayesian network analysis of multi-compartmentalized immune responses in a murine model of sepsis and direct lung injury

Fig. 4

Consensus Bayesian network obtained for blood data sets. Mice (n = 10–12/group) were given IT injections of saline, acid, or particles (lung insult) with or without the additional insult of cecal ligation and puncture (CLP). CLP was performed at intervals relative to the aspiration injury (injury interval), either immediately before the IT injection (0 h) or preceding them by 12 or 48 h. There were a total of 12 combinations of CLP, lung insult and insult interval. All mice were euthanized at 6 h post-IT injection. Blood was collected and plasma obtained for cell counts and cytokine levels. The data sets were analyzed in Bayesian Networks. When interactions occurred in the same direction in all of the networks, these are represented as directed edges (arrows), whereas those appearing at least once in an opposing direction are represented as undirected edges (no arrowhead). CLP refers to the presence of sepsis. Injury Interval is the time interval between the induction of sepsis and the lung insult (none, 0, 12, or 48 h) and Lung Insult refers to the aspiration (saline, acid, or particles)

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