Fig. 2

In panel a, the in vivo activity of the Carlon generic product of amikacin compared with the innovator (BMS). The non-significant P value of the curve-fitting analysis (0.055) indicates that the generic is therapeutically equivalent to the innovator, however the higher data dispersion reduced the power of the test to detect significant differences from 87 % to 63 %. In panel b, the in vivo activity of eight generic products of amikacin compared with the innovator (BMS). The global curve-fitting analysis (P < 0.05) demonstrates that the generics are described by independent curves, characterized by reduced E _max compared with the innovator (see Table 3), indicating that they lack therapeutic equivalence, despite similar in vitro activity