Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy

Table 4 Multivariable logistic regression analysis for factors associated with AKI (179 patients and 22 with AKI)

Risk factor	Odds ratio (95 % CI)	P	Reliability^a (%)
Antibiotic group		0.01	84.6
Vanc versus combV/P	0.14 (0.04, 0.52)	0.004
Piptazo versus combV/P	0.91 (0.22, 3.82)	0.89
Vanc versus piptazo	0.15 (0.03, 0.83)	0.03
Sex (male/female)	0.28 (0.10, 0.79)	0.02	67.4
Baseline creatinine clearance (per 10 ml/min increase)	1.15 (1.00, 1.33)	0.05	65.4
Race (African-American/Caucasian)	5.34 (0.62, 46.4)	0.13	57.3
Skin/soft tissue infection (yes/no)	0.22 (0.05, 1.05)	0.06	52.1

Risk factors with reliability less than 50 % included pneumonia (48 %), hypertension (33 %), BMI (28 %), NSAIDS (25 %), bone or joint infection (19 %), diabetes (13 %), HIV (11 %), and total number of comorbidities (10 %)
^aPercentage of times each risk factor appeared in 1000 bootstrap multivariable analyses. Risk factors with reliability <50 % were not included in the multivariable model

ISSN: 1756-0500