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Table 4 Multivariable logistic regression analysis for factors associated with AKI (179 patients and 22 with AKI)

From: Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy

Risk factor Odds ratio (95 % CI) P Reliabilitya (%)
Antibiotic group   0.01 84.6
 Vanc versus combV/P 0.14 (0.04, 0.52) 0.004  
 Piptazo versus combV/P 0.91 (0.22, 3.82) 0.89  
 Vanc versus piptazo 0.15 (0.03, 0.83) 0.03  
Sex (male/female) 0.28 (0.10, 0.79) 0.02 67.4
Baseline creatinine clearance (per 10 ml/min increase) 1.15 (1.00, 1.33) 0.05 65.4
Race (African-American/Caucasian) 5.34 (0.62, 46.4) 0.13 57.3
Skin/soft tissue infection (yes/no) 0.22 (0.05, 1.05) 0.06 52.1
  1. Risk factors with reliability less than 50 % included pneumonia (48 %), hypertension (33 %), BMI (28 %), NSAIDS (25 %), bone or joint infection (19 %), diabetes (13 %), HIV (11 %), and total number of comorbidities (10 %)
  2. aPercentage of times each risk factor appeared in 1000 bootstrap multivariable analyses. Risk factors with reliability <50 % were not included in the multivariable model